Innovations transform our research traditions and become the driving force to advance individual, group, and social creativity. Meanwhile, interdisciplinary research is increasingly being promoted as a route to advance the complex challenges we face as a society. In this paper, we use Latent Dirichlet Allocation (LDA) citation as a proxy context for the diffusion of an innovation. With an analysis of topic evolution, we divide the diffusion process into five stages: testing and evaluation, implementation, improvement, extending, and fading. Through a correlation analysis of topic and subject, we show the application of LDA in different subjects. We also reveal the cross-boundary diffusion between different subjects based on the analysis of the interdisciplinary studies. The results show that as LDA is transferred into different areas, the adoption of each subject is relatively adjacent to those with similar research interests. Our findings further support researchers' understanding of the impact formation of innovation.

Not only did COVID-19 give rise to a global pandemic, but also it resulted in an infodemic comprising misinformation, rumor, and propaganda. The consequences of this infodemic can erode public trust, impede the containment of the virus, and outlive the pandemic itself. The evolving and fragmented media landscape, particularly the extensive use of social media, is a crucial driver of the spread of misinformation. Focusing on the Chinese social media Weibo, we collected four million tweets, from December 9, 2019, to April 4, 2020, examining misinformation identified by the fact-checking platform Tencent-a leading Chinese tech giant. Our results show that the evolution of misinformation follows an issue-attention cycle pertaining to topics such as city lockdown, cures and preventive measures, school reopening, and foreign countries. Sensational and emotionally reassuring misinformation characterizes the whole issue-attention cycle, with misinformation on cures and prevention flooding social media. We also study the evolution of sentiment and observe that positive sentiment dominated over the course of Covid, which may be due to the unique characteristic of "positive energy" on Chinese social media. Lastly, we study the media landscape during Covid via a case study on a controversial unproven cure known as Shuanghuanglian, which testifies to the importance of scientific communication in a plague. Our findings shed light on the distinct characteristics of misinformation and its cultural, social, and political implications, during the COVID-19 pandemic. The study also offers insights into combating misinformation in China and across the world at large.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is spreading at an alarming rate, and it has created an unprecedented health emergency threatening tens of millions of people worldwide. Previous studies have indicated that SARS-CoV-2 ribonucleic acid could be detected in the feces of patients even after smear-negative respiratory samples. However, demonstration of confirmed fecal-oral transmission has been difficult. Clinical studies have shown an incidence rate of gastrointestinal (GI) symptoms ranging from 2% to 79.1% in patients with COVID-19. They may precede or accompany respiratory symptoms. The most common GI symptoms included nausea, diarrhea, and abdominal pain. In addition, some patients also had liver injury, pancreatic damage, and even acute mesenteric ischemia/thrombosis. Although the incidence rates reported in different centers were quite different, the digestive system was the clinical component of the COVID-19 section. Studies have shown that angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, was not only expressed in the lungs, but also in the upper esophagus, small intestine, liver, and colon. The possible mechanism of GI symptoms in COVID-19 patients may include direct viral invasion into target cells, dysregulation of angiotensin-converting enzyme 2, immune-mediated tissue injury, and gut dysbiosis caused by microbiota. Additionally, numerous experiences, guidelines, recommendations, and position statements were published or released by different organizations and societies worldwide to optimize the management practice of outpatients, inpatients, and endoscopy in the era of COVID-19. In this review, based on our previous work and relevant literature, we mainly discuss potential fecal-oral transmission, GI manifestations, abdominal imaging findings, relevant pathophysiological mechanisms, and infection control and prevention measures in the time of COVID-19.

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