Lung cancer occurred in approximately 1,8 million patients and caused an estimated 1,6 million deaths in 2012, worldwide. NSCLC constitutes approximately 85% of all lung cancers. Patients with early-stage NSCLC are surgically treated for curative goals. However, many patients are at risk of recurrence despite complete resection. This suggests that a large proportion of patients have the micrometastatic disease even at the early course of the disease. In this review, we aimed to evaluate the results of adjuvant chemotherapy, targeted therapy and immunotherapy studies to improve survival in NSCLC.

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Specific ABO blood group and Rh antigens are found to be associated with several malignancies and lung cancer. However, the relationship between blood type and Epidermal Growth Factor Receptor (EGFR) mutation in lung cancer remains poorly investigated. Material and Methods: In this retrospective case-control study, 105 EGFR mutation-positive and 169 EGFR mutation-negative lung adenocarcinoma patients were included. Baseline characteristics of the patients were determined. Odds ratios were calculated for the relationship of EGFR mutation positivity according to the ABO and Rh blood type. Overall survival difference according to the blood types was analyzed in metastatic patients that were diagnosed in the EGFR-mutant group. Results: There was no statistically significant increase observed in the relationship of EGFR mutation positivity for any of ABO and Rh types (OR and p-value, respectively; A

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