Objective:  To provide information about clinical manifestation human Papillomavirus infection  Methods: This article is literature review. The searching method used  pubmed database from last 10 years. Review: Human Papillomavirus infection is caused by Papillomaviridae, it made proliferation mucosa epitel and skin. More than 100 genotype viral has been identified, human Papillomavirus strain was classification based on oncogenic and non oncogenic type. The diagnosis was based on clinical features, histopathology and molecular biology. Therapy human Papillomavirus infection was based on morfologi, distribution, account of lesion, choice of patient and skill of practitionerConclusion:  Patient with history of infection human Papillomavirus can be reccuren

BACKGROUND Before COVID-19, it was recommended that medical education be conducted using the blended learning method in order to achieve an effective learning experience. However, it seems that distance learning is currently the best alternative to the previous learning method. Clinical skills lab activities, which are one of the learning methods in medical education, must adapt because they cannot be administered in-person. Social media has been proven giving a potential to supplement formal medical education for undergraduate student. OBJECTIVE This systematic review aims to examine the effectiveness of media social use as a supplement for clinical skills lab learning on undergraduate medical students in low- and middle-income countries (LMIC) during the COVID-19 pandemic. METHODS We designed a protocol for creating a systematic review on the effectiveness of social media as a supplement media in clinical skills lab learning for undergraduate medical students in LMIC during COVID-19. We will be extracting information from appropriate sources online obtained from journal websites’ databases guided by the PRISMA-S checklist in accordance with the research problem. The included sources include randomized controlled trials, systematic review, and meta-analysis published between 2020-2021. RESULTS This manuscript is still a protocol and has not been implemented. CONCLUSIONS In this systematic review, we will discuss the effectiveness of social media as a clinical skills lab learning for undergraduate medical students in LMIC during the COVID-19 pandemic.