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It was aimed to compare the year we started using telestroke application in ischemic stroke patients with the previous year in which we did not use telestroke application in terms of patient prognosis. Material and Method:Stroke patients presenting for whom WhatsApp was used for telestroke purposes, were evaluated as the telestroke group. The previous year it was a pre-telestroke group. In this prospectively planned study, the pre-telestroke and telestroke groups were compared in terms of age, gender, chronic disease characteristics, onset of symptoms, aspirin, warfarinuse, door-to-CT, door-to-consultation and door-to-treatment times, prognosis, and 30-day mortality.Results: A total of 727 patients clinically and radiologically confirmed to have ischemic stroke were included in the study. There were 252(34.6%) patients in the pre-telestroke group and 475 (65,4%) patients in the telestroke group. Both rtPA and thrombectomy treatment were significantly higher in the telestroke group (p<0.001). In the first 24-hour evaluation, the rate of discharge increased and hospital admission and mortality decreased in the telestroke group (p<0.001). There was no statistically significant difference between the groups in terms of poor prognosis and 30-day mortality (p=0.470 and p=0.625, respectively). Conclusion:Telestroke practices not only provide access to there levant clinical branch for early consultation but also facilitate time lytreatment thus leading to improvement in prognosis.

AIM: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder resulting in degeneration of certain neuronal structures in certain brain regions and severe neuronal loss, characterized by a pathological accumulation of senile amyloid plaques (SP) and neurofi brillary tangles (NFT) within the brain . Alzheimer's disease has been associated with Type 2 diabetes mellitus (T2DM) in recent years. We designed our study on the relationship between AD and T2DM. Genome screening studies in different populations had linked the chromosome 12q24 region to type 2 diabetes. Within this region, there is the PSMD9 gene encoding a transcriptional coactivator of insulin production. METHOD: The effect of PSMD9 gene E197G (rs14259) polymorphism on AD was investigated in29 Alzheimer's patients and 25 healthy controls, who were included in the study. RESULTS: In our study, it was determined that the variant of PSMD9 gene E197G (rs14259) did not cause genetic risk factor for Alzheimer's disease in Turkish population. CONCLUSIONS: Our study was the fi rst to investigate the relationship between PSMD9 gene and Alzheimer's disease. A larger sample group is needed to investigate the contribution of the PSMD9 gene to Alzheimer's disease in further studies (Tab. 5, Ref. 8).

Neurofibrillar tangles formed by the accumulation of hyperphosphorylated tau proteins in the intracellular space and the senile plaques formed by amyloid β (Aβ) accumulating in extracellular environment are shown as two main elements of Alzheimer's disease (AD). In our study, the relationship between the risk of Alzheimer's disease and TNFα rs1799724 polymorphism in the Turkish population was investigated. Our study is the first report investigating the relationship between the risk of Alzheimer's disease and TNFα rs1799724 gene polymorphism in Turkish population. No significant relation was found for rs1799724 polymorphism in AD patients. Since TNFα rs1799724 gene polymorphism was also associated with type 2 diabetes mellitus (T2DM), the polymorphism also was evaluated in T2DM within the AD patients group. According to our results rs1799724 polymorphism was found to be a significant relationship with T2DM within AD patients group. On the other hand, there was no significant difference between fasting blood glucose values of AD patients and-857C>T (rs1799724) polymorphism. According to our results,-857C>T rs1799724 polymorphism may have a relationship with T2DM as independent from AD.

Objective: To assess changes in blood gas parameters, such as pH, partial carbon dioxide pressure (PaCO2), bicarbonate (HCO3), base deficit, and lactate values, in patients who present to the emergency care unit after a seizure. Methods: This is a prospective study on patients who suffered a generalized tonic-clonic seizure. The demographic and biochemical data of the patients and their blood gas parameters were recorded both at the time of presentation to the emergency department and during the follow-up examination. Results: A total of 68 patients were included in the study. Among the patients, 60.3% (41) were male. The median age of the patients was 43 years (IQR: 29-65.25). The median initial lactate value was 5.7 mmol/L (25th and 75th percentiles: 3.5–8.5 mmol/L). The median follow-up lactate value was 1.8 mmol/L (25th and 75th percentiles: 1.1–2.8 mmol/L). The statistical analysis of the blood gas parameters revealed a statistically significant difference in the pH, PaCO2, base deficit, and lactate values between the initial and follow-up evaluations (P<0.001). Conclusion: The results of our study suggest that metabolic acidosis with high anion gap may develop due to the increase in the lactate levels as a result of a tonic-clonic seizure.