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The current findings suggest that propofol improves NPE likely via IAA accumulation and the regulation of EAA and IAA balance, which may represent an effective treatment for NPE.

Immunosuppression due to ischemic stroke is a pivotal factor that can increase the incidence of infectious diseases and mortality after stroke. Electroacupuncture (EA) has been confirmed to improve the prognosis of ischemic stroke model through the parasympathetic nervous system (PNS). The role of EA in regulating immunosuppression after ischemic stroke through PNS is unclear. Using ischemic stroke model, the experiment found that EA exerted the effects in improving survival rate, and neurological deficits, reducing infarct volume, proportion of neuronal apoptosis, and systemic inflammation. Importantly, mice received EA showed a significantly higher in weight, cell number, and α7nAChR levels of spleen, suggesting the improvement of immunosuppression; EA also activated dorsal motor nucleus of the vagus which was the main source of vagus, the main component of the PNS. However, none of these changes were found in mice that did not receive EA. Taken together, EA improves the prognosis of ischemic stroke by activating PNS and regulating spleen immune function in mice.