No abstract

Network-on-Chip (NoC) can be evaluated from various aspects, such as communication latency, throughput, and power consumption. The preference of these requirements depends on each application. An on-chip variable-pipeline (VP) router that can adapt to these requirements by dynamically reconfiguring its data path structure is proposed in this paper. In response to the communication pattern, it can change the pipeline structure, supply voltage, and operational frequency using the dynamic voltage and frequency scaling (DVFS). As the traffic load becomes high, the VP router uses a look-ahead twocycle pipeline structure for exploiting the maximum frequency, while it behaves as a one-cycle router when a low latency is preferred. A three-cycle pipelined structure with an adaptive routing enables to dynamically avoid hotspots. Instead of a simple pipeline-stage unification which causes rapid decrease of the operating frequency, by speculatively executing multiple pipeline stages in parallel, the operating frequency gracefully decreases as the number of the pipeline stages increases. Simulation results show that the one-cycle mode offers the shortest communication latency, while the two-cycle mode achieves the highest throughput for SPLASH-2 benchmarks.

No abstract

Marine sponge-associated bacteria are known as bio-active compound produce. We have constructed metagenome libraries of the bacteria and developed a metagenomic screening approach. Activity-based screening successfully identified novel genes and novel enzymes; however, the efficiency was only in 1 out of 104 clones. Therefore, in this study, we thought that bioinformatics could help to reduce screening efforts, and combined activity-based screening with database search. Neutrophils play an important role for the immune system to recognize excreted bacterial by-products as chemotactic factors and are recruited to infection sites to kill pathogens via phagocytosis. These excreted by-products are considered critical triggers that engage the immune system to mount a defense against infection, and identifying these factors may guide developments in medicine and diagnostics. We focused on genes encoding amino acid ligase and peptide synthetase and selected from an in-house sponge metagenome database. Cell-free culture medium of each was used in a neutrophil chemiluminescence assay in luminol reaction. The clone showing maximum activity had a genomic sequence expected to produce a molecule like a phospho-N-acetylmuramyl pentapeptide by the metagenome fragment analysis.

CONCLUSIONS: Together, these findings support the concept that the NO-CSF1Ri combination can act as a therapeutic agent that restores control over TME, which in turn could improve the outcomes of PCa patients.