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Outbound container storage location assignment problem (OCSLAP) could be defined as how a series of outbound containers should be stacked in the yard according to certain assignment rules so that the outbound process could be facilitated. Considering the NP-hard nature of OCSLAP, a novel particle swarm optimization (PSO) method is proposed. The contributions of this paper could be outlined as follows: First, a neighborhood-based mutation operator is introduced to enrich the diversity of the population to strengthen the exploitation ability of the proposed algorithm. Second, a mechanism to transform the infeasible solutions into feasible ones through the lowest stack principle is proposed. Then, in the case of trapping into the local solution in the search process, an intermediate disturbance strategy is implemented to quickly jump out of the local solution, thereby enhancing the global search capability. Finally, numerical experiments have been done and the results indicate that the proposed algorithm achieves a better performance in solving OCSLAP.

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The cellular redox state is essential for inhibiting ferroptosis. Progranulin (PGRN) plays an important role in maintaining the cellular redox state after ischemic brain injury. However, the effect of PGRN on ferroptosis and its underlying mechanism after cerebral ischemia remains unclear. This study assesses whether PGRN affects ferroptosis and explores its mechanism of action on ferroptosis after cerebral ischemia. We found endogenous PGRN expression in microglia increased on day 3 after ischemia. In addition, PGRN agonists chloroquine and trehalose upregulated PGRN expression, reduced brain infarct volume, and improved neurobehavioral outcomes after cerebral ischemia compared to controls ( p < 0.05). Moreover, PGRN upregulation attenuated ferroptosis by decreasing malondialdehyde and increasing Gpx4, Nrf2, and Slc7a11 expression and glutathione content ( p < 0.05). Furthermore, chloroquine induced microglial lysosome PGRN release, which was associated with increased neuron survival. Our results indicate that PGRN derived from microglial lysosomes effectively inhibits ferroptosis during ischemic brain injury, identifying it as a promising target for ischemic stroke therapy.