Failures of communication, documentation errors, and various system failures may lead to an untoward outcome for the patient. We devised a simple system to ensure that significant unexpected findings on imaging received appropriate attention. An additional level of redundancy has increased the probability of optimal patient outcome.

Although the use of ultrasound as a therapeutic agent in the field of physical medicine continues to grow, there are still a number of questions concerning its physiologic effects which remain unanswered. With regard to the thermal response, it is generally accepted that practically the entire amount of energy applied to the tissues through this medium is absorbed and converted into heat. As a result, there is a rise in tissue temperature, most marked in the bones and nerves in which selective heating appears to occur (1-3). The effect of ultrasound on blood flow has been investigated by a number of workers. Bickford and Duff (4) reported that in man, exposure of the forearm to 2 watts per square centimeter produced minor increases in local circulation in one-half the cases and no change in the others, while only with dosages of 3-334 watts was a significant augmentation consistently noted. Paul and Imig (5) performed a similar study and obtained essentially the same results. In the case of dogs, Paul and his associates (5, 6) found 1 watt per square centimeter to be an effective quantity of ultrasonic irradiation for the production of a vascular response. In the present study it was decided to

Lymphocyte function-associated antigen 3 (LFA-3) is a widely distributed cell surface glycoprotein that has been assigned a role in cell-cell adhesion on the basis of its capacity to bind to the T-lymphocyte CD2 antigen. The amino acid sequences of the extracellular domains of these two antigens, predicted from their cDNA sequences, show significant similarities, and both are members of the immunoglobulin supergene family. In this communication, a probe prepared from LFA-3 cDNA has been used in Southern blot analyses of somatic cell hybrids and in in situ hybridization to assign the LFA-3 gene to the human chromosome band 1p13. This is the same location previously assigned to CD2. Thus the LFA-3 and CD2 genes have probably arisen by duplication of a common evolutionary precursor. These genes therefore represent a further instance in which related members of the immunoglobulin superfamily are located in adjacent regions of the genome.

No abstract

In 17 experiments, performed on the forearm of normal subjects, the effect of 2½, 5, and 10 min of arterial occlusion was studied. Blood flow was obtained with the venous occlusion plethysmograph, and oxygen uptake was calculated using the Fick principle. Arterial occlusion resulted in the production of an oxygen debt which was subsequently repaid. With progressively longer periods of anoxia there was a proportionate increase in the magnitude of the debt. Similar conclusions could not be drawn from blood flow studies alone, since the vascular change represented only one means of repayment of the oxygen debt during reactive hyperemia, the other being a greater extraction of oxygen from each unit of blood early in the postocclusion period. The constant overswing on either side of the control base line, observed in the records of oxygen uptake, suggested the absence of delicately balanced and efficient checks on the mechanisms responsible for repayment of the oxygen debt incurred in the period of tissue anoxia. Submitted on March 27, 1961