Following Dirac and Weyl semimetals, nodal line semimetals represent a new type of topological semimetal and attracted extensive interest in modern condensed matter physics. Recently, a kind of hybrid nodal lines have been proposed (Zhang et al 2018 Phys.Rev. B 97 125143) and it mainly come from anisotropy interaction. Based on the first-principle calculations and k·p model, we predict a cubic Be 2 Si with topological nontrivial electronic states exhibiting fascinating type-I and type-II hybrid nodal line around Fermi level. Unexpectedly the low energy electronic states of Be 2 Si are isotropy in k x and k y directions and a new effective model has been proposed for the appearance of this new type hybrid nodal line. The four-fold degenerated type-I and type-II nodal points in the hybrid nodal lines along the high symmetry lines of Γ-K and Γ-X are protected by mirror reflection, time reversal and space inversion symmetry. The spin-orbit coupling effect only induces slight band gap in the hybrid nodal lines in Be 2 Si whose nontrivial nature remains. Moreover, the nontrivial hybrid nodal lines in Be 2 Si are robust to external strain. The results in present work indicate that Be 2 Si are promising candidates for future experimental studies of nontrivial topological semimetals and an excellent platform to study the interaction between the two types Dirac fermions.

e aim of this study is to comprehensively evaluate the associations of IGFBP3 and IGF1 polymorphisms with susceptibility to colorectal cancer (CRC). We searched the English and Chinese databases and recruited case-control studies based on strict inclusion and exclusion criteria. e statistical analysis was performed by the Comprehensive Metaanalysis 2.0 (CMA 2.0) so ware and this initially identi ed 251 studies. We then recruited 10 English studies to this metaanalysis detailed review which includes 9,415 CRC patients and 14,179 healthy controls. Our results demonstrated that IGFBP3 rs2854746 C>G polymorphism increases susceptibility to the CRC (allele model: OR=1.167, 95% CI=1.095~1.244, p<0.001 and to the dominant gene model: OR=1.226, 95% CI=1.113~1.350, p<0.001); but IGFBP3 rs2854744 A>C has no signi cant association with the CRC susceptibility (allele model: OR=0.970, 95% CI=0.932~1.010, p=0.138; dominant gene model: OR=0.995, 95% CI=0.936~1.057, p=0.874). Also, IGF1 rs35767 C>T polymorphism decreases susceptibility to CRC (allele model: OR=0.785, 95% CI=0.726~0.850, p<0.001 and also the dominant model: OR=0.730, 95% CI=0.661~0.806, p<0.001). However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective.