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Abstract.A NCAR-CCSM3 (National Center for Atmospheric Research -Community Climate System Model version 3) state-of-the-art transient paleoclimate simulation with prescribed freshwater inflows is used to investigate the changes and evolution of the South Atlantic water mass structure from the Last Glacial Maximum (LGM) to the present day. Model results show that 21

For the first time, we demonstrated that GO can be specifically directed to the tumor neovasculature in vivo through targeting of CD105, a marker of tumor angiogenesis. The versatile chemistry of graphene-based nanomaterials makes them suitable nanoplatforms for future biomedical research, such as cancer theranostics.