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An efficient route to synthesise a wide range of W,A'-R,R-4-(2-oxo-l,2-dihydroquinolin-6-yloxy)butanamide, specially Cilostamide (R = methyl and R = cyclohexyl), one of the most selective inhibitors of phosphodiesterases (PDE3) enzyme, from 5-methoxy-2-nitro benzaldehyde with emphasis on the preparation of the carbostyril (2-quinolinone) ring system is reported.

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New 10H-benzo [b]pyridazino [3,4-e][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.

Facile Synthesis of New [1,2,4]Triazolo[4,3-b]pyridazine. -A wide range of the title pyridazines are obtained by two facile routes, either cyclocondensation of substituted hydrazino pyridazines (I) with orthoesters or oxidative cyclization of their hydrazone analogs using nitrobenzene as oxidizing agent. Some other new derivatives are synthesized from (I) by sequential treatment with carbon disulfide and alkyl halides. -(ARGHIANI, Z.; SEYEDI, S. M.; BAKAVOLI*, M.; ESHGHI, H.; J. Heterocycl. Chem. 52 (2015) 4, 1099-1107, http://dx.