Background This study aimed to examine the effect of the combination of yoga training with high vitamin D dose supplementation on the expression and systemic levels of inflammatory cytokines and psychophysical status of breast cancer survivors. Methods Thirty volunteered breast cancer survivors (48 ± 8 years) were randomly allocated to a high dose (4000 IU) of vitamin D supplementation (HD) group (n = 10), yoga with a high dose of vitamin D (YHD) group (n = 10), and yoga with a low dose (2000 IU) of vitamin D (YLD) group (n = 10). Participants performed the Hatha yoga style for 12 weeks, twice a week. Blood samples, quality of life (QoL) questionnaire, and physical performance tests were taken before and after the intervention. Results Body fat percentage (ηp2 = 0.36), handgrip strength (ηp2 = 0.41) and QoL indicators include global health (ηp2 = 0.54), functional scales (ηp2 = 0.49), and symptoms scales (ηp2 = 0.50) were significantly improved in the both YHD and YLD groups compared to the HD group (p < 0.05). Also, interleukin-10 (IL-10) levels were markedly increased in the Y-HVD group compared to the Y-LVD and HVD groups. Moreover, there were significant decreases in tumor necrosis factor-α (TNF-α) and interleukin-6 levels in the Y-HVD group after the intervention. The anti-inflammatory index (IL-10/TNF-α) was significantly increased in both the yoga groups (P < 0.05). Conclusion Yoga promotes physical and psychological fitness and, in combination with a high dose of vitamin D, improves the cytokine profile, which can effectively manage the side effects associated with cancer. Trial registration IRCT20210726051993N2. Registration date: 2022/02/27. URL: https://www.irct.ir/trial/62079

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The present study has been carried out to evaluate the concentration of copper (Cu) and vanadium (V) elements in the muscle, skin, and gill tissues of Tylosurus crocodilus (Belonidae), an edible fish, in the Bahregan region which is located in the northern part of the Persian Gulf. For this purpose, 18 fish samples in three different length groups (small, medium, and large) were randomly collected in Bahregan region. Tissues were separated and concentration of the heavy metals was determined by atomic absorption. The results showed that mean concentration of Cu and V were 0.2851 ± 0.10036 and 1.1368 ± 0.12405, 0.1117 ± 0.02322 and 2.5091 ± 1.14201 and 0.1803 ± 0.03204 and 3.3133 ± 1.05995 µg g -1 dry weight, in skin, muscle and gill tissues, respectively. Also, the results revealed a significant positive correlation between the standard length and Cu concentration in the muscle and gill tissues (P ≤ 0.05), as well as between the standard length and V concentration in all the tissues (P ≤ 0.05). The results indicated that the concentration of V was higher than the World Health Organization (WHO) standard but the concentration of Cu was lower. It is therefore highly recommended that usage of this carnivore species in the studied area is limited because of the high accumulation of V in its muscle tissue.