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The nCoV-19 in a short period of time, in lower than two months has been spread as a pandemic in all over the world. This novel type of Coronavirus which shows itself with coughing, sneezing, fatigue and respiratory symptoms which is similar to cold illness has killed more than 100,000 people. However, many protocols have been established to minimize the number of infected people, but without any border and regardless the nationality, this virus has been spread in all countries. In this review, with broad mechanistic and interdisciplinary consideration the dentistry pathways of transmission, physiology, effective and available drugs and their biological inhibiting pathways have been discussed. Among many reasons that have caused higher rate of spreading, the dental services and surgeries involve to professional-patient close contacts could be seen as one of the probable pathways of transmission for this virus. According to the more recently reported literatures, the blueprint of many individual and instrumental reasons in dentistry, could be observed in nCoV-19 infection and spreading which raise the concern of the professionals about the efficiency of conventional antiviral methods. So, results of many studies attributed to the facts that the superhydrophobic antiviral materials and surfaces are potential candidates for designing dentistry instruments with more antiviral properties.

In this study, the in vivo antioxidant and antihypertensive properties of peptides HL-7 with the sequence of YLYELR and HL-10 with the sequence of AFPYYGHHLG were identi ed from scorpion venom of H. lepturus were evaluated. To study the in vivo effects of peptides, D-galactose-induced and DOCA saltinduced mice models were used. The results of the antioxidant assay for both peptides showed that the activity of serum and liver catalase (CAT), as well as superoxide dismutase (SOD) enzymes, was signi cantly decreased in the D-galactose-induced group (NC), while MDA levels were increased in serum and the liver tissue samples (p<0.01). Compared with the D-galactose-induced mice, the peptide treated mice group had a higher activity of antioxidant enzymes namely CAT and SOD, as well as a lower lipid peroxidation level. Also, the results of antihypertensive activity for both peptides showed that systolic blood pressure (SBP) and diastolic blood pressure (DBP) of the mice treated with the HL-7 and HL-10 peptides were signi cantly reduced in a dose-dependent manner (p<0.01). The administration of the HL-7 peptide at doses of 5 mg/kg BW (LP1) and 15 mg/kg BW (HP1) signi cantly diminished the mean arterial blood pressure (MAP) by 31 mmHg and 40.47 mmHg, respectively. Accordingly, treatment of mice with the HL-10 peptide at doses of 5 mg/kg BW (LP2) and 15 mg/kg BW (HP2) considerably lowered the MAP by 18.3 mmHg and 21.93 mmHg, respectively. Our ndings suggest that both the HL-7 and HL-10 peptides could be potentially utilized as antihypertensive and antioxidant components.