As a bio-compatible/degradable polymer, poly(lactic acid) (PLA) has been widely noticed in tissue engineering and medical applications. Proper catalytic ringopening polymerization of lactic acid is pertinent to development of active metal species capable of producing high-molecular-weight polymers. In this work, ligand catalyst (2,4-di-tertio-butyl-6-{[(2-di-methyl-amino ethyl) methyl amino] methyl} phenol) was synthesized and then attached to Fe-based and Zn-based metal substitutes, and performance of metal species toward ring opening polymerization of lactic acid has been investigated. Regulation of reaction condition at 180 C for 36 h with Zn-based catalyst allowed for late-stage production of a high-molecular-weight PLA, while Fe-based facilitated polymerization at early stages leading to PLAs with comparatively twofold higher molecular weight at lower time, monomer-to-initiator ratio, and temperature (at 170 C). A ratio of monomer to initiator of 5000 with Fe catalyst resulted in the highest molecular weight. Thus, polymerization has been facilitated by the use of Fe-based catalyst. For this class of catalyst with Fe substitute, the product was characterized by means of 1 H-NMR, Fourier transform infrared spectroscopy, and differential scanning calorimetry analyses. J. VINYL ADDIT. TECHNOL., 25:215-224, 2019.