We present an efficient approach to optimizing pulse sequences for implementing fast entangling two-qubit gates on trapped ion quantum information processors. We employ a two-phase procedure for optimizing gate fidelity, which we demonstrate for multi-ion systems in linear Paul trap and microtrap architectures. The first phase involves a global optimization over a computationally inexpensive cost function constructed under strong approximations of the gate dynamics. The second phase involves local optimizations that utilize a more precise ordinary differential equation description of the gate dynamics, which captures the nonlinearity of the Coulomb interaction and the effects of finite laser repetition rate. We propose two gate schemes that are compatible with this approach, and we demonstrate that they outperform existing schemes in terms of achievable gate speed and fidelity for feasible laser repetition rates. In optimizing sub-microsecond gates in microtrap architectures, the proposed schemes achieve orders-of-magnitude-higher fidelities than previous proposals. Finally, we investigate the impact of pulse imperfections on gate fidelity and evaluate error bounds for a range of gate speeds.

Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. The results of these studies are promising. This review summarizes data on pharmacological ascorbate (1) as a safe and efficacious adjuvant to cancer therapy; (2) as a selective radiosensitizer of cancer via a mechanism involving hydrogen peroxide; and (3) as a radioprotector in normal tissues. Additionally, we present new data demonstrating the ability of pharmacological ascorbate to enhance radiation-induced DNA damage in glioblastoma cells, facilitating cancer cell death. We propose that pharmacological ascorbate may be a general radiosensitizer in cancer therapy and simultaneously a radioprotector of normal tissue.

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We theoretically investigate the use of fast pulsed two-qubit gates for trapped ion quantum computing in a two-dimensional microtrap architecture. In one dimension, such fast gates are optimal when employed between nearest neighbors, and we examine the generalization to a two-dimensional geometry. We demonstrate that fast pulsed gates are capable of implementing high-fidelity entangling operations between ions in neighboring traps faster than the trapping period, with experimentally demonstrated laser repetition rates. Notably, we find that without increasing the gate duration high-fidelity gates are achievable even in large arrays with hundreds of ions. To demonstrate the usefulness of this proposal, we investigate the application of these gates to the digital simulation of a 40-mode Fermi-Hubbard model. This also demonstrates why shorter chains of gates required to connect arbitrary pairs of ions make this geometry well suited for large-scale computation.