Introduction: Liver is the most commonly involved organ by metastatic disease. Secondary tumors are more frequent lesion forming more than 75%, while primary cancers of liver formed less than 25%. Imaging according to LI-RAD can give a clue for the nature of the primary lesion of live particularly hepatocellular carcinoma.  Liver biopsy is still the golden standard surveillance for histopathological diagnosis of liver tumor; however, it is a traumatic procedure, but its value in reaching the definite diagnosis is superior to imaging technique. Tru cut biopsy is less traumatic than open biopsy and considered nowadays as the preferable technical way in sampling liver tissue that can be applied for both histopathology and immunohistochemistry. Secondary liver lesions were encountered to be originated from lung, breast, Pancreatobiliary tract and GIT, female genital tract, prostate and others.  Objectives of the Study: To assess the efficacy of Tru cut biopsy for both histopathological examination and immunohistochemical study identification the type and origin of liver tumors. Methodology: This is a cross sectional study conducted in the Al-Sadr Teaching Hospital in Al-Najaf City, Iraq from January 2019 till December 2021.