Objective. To define 24-h characteristics of arterial blood pressure in healthy adolescent girls and boys; to determine gender-related differences of blood pressure, its circadian pattern. Material and methods. The 24-h blood pressure was monitored hourly in healthy girls (n=22, without no account for the menstrual cycle phase) and boys (n=22). Additionally, blood pressure of adolescent girls (n=15) was examined during different phases of their menstrual cycle (follicular, ovulation, and luteal). Blood pressure was monitored with an auto-cuff automatic outpatient blood pressure monitor. Results. Investigation showed gender-related differences in 24-h blood pressure. Study results revealed the circadian blood pressure rhythm characterized by a period of low values during nighttime and an early morning increase in both adolescent groups. Nocturnal systolic blood pressure was higher (P<0.05) in boys than in girls in all phases of their menstrual cycle. Diurnal systolic blood pressure in boys was higher than in girls in their follicular phase (P<0.05). The day and night blood pressure differed between boys and girls (P<0.05). A dipping blood pressure pattern as a decrease in mean nighttime blood pressure as compared with mean daytime blood pressure was defined: 10.02±6.7% in girls (n=22) and 13±6.3% in boys (n=22), without genderrelated differences (P>0.05). There were no differences in blood pressure dipping among girls’ groups in different menstrual cycle phases (P>0.05). Adolescent boys showed a significant positive correlation between their mean diurnal blood pressure and height (P<0.05). Conclusion. The study proved gender-related arterial blood pressure differences in healthy adolescents. The results demonstrate the gender-specific circadian blood pressure rhythm pattern in both gender groups.

Objective: to define peculiarities of urinary magnesium (Mg) excretion in diabetic adolecents; to elucidate gender-related differences in Mg urinary excretion; to determine urinary Mg excretion differences between diabetic and age-matched healthy children. The diurnal, nocturnal and 24–h urinary Mg level in adolescent boys and girls (aged 13–17 years) with type I diabetes mellitus (DM) and in age-matched control groups of healthy boys and girls was examined. Additionally the adolescent girls were examined during different phases of their menstrual cycle. Results: Diurnal, overnight and 24–h Mg urinary excretion in diabetic adolescent boys and girls was significantly higher than in healthy ones. In diabetic boys 24 h Mg excretion was higher than in diabetic girls (4.59±1.4 vs. 3.34±1.5 mmol; p<0.05). The investigation showed gender-related differences in Mg urinary excretion in healthy adolescents: 24–h Mg urinary excretion was significantly higher in boys than in girls (2.66±0.9 vs. 2.1±0.9 mmol; p<0.05). The level of Mg in the nocturnal urine of boys and girls was significantly higher than in diurnal. Urine Mg was negatively related to height in adolescent girls. Conclusion: Diabetic adolescents excrete significantly more Mg with urine as compared to healthy ones.

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Reikšminiai žodžiai: streptokokinis tonzilitas, ūminis reumatas, ūminis glomerulonefritas, prieryklinis pūlinys, pediatrinis autoimuninis neuropsichiatrinis sutrikimas, susijęs su streptokokine infekcija (PANDAS). Darbo tikslas. Gydytojų budrumas streptokokinių komplikacijų atžvilgiu yra sumažėjęs. Be to, išsiaiškinta naujų komplikacijų, kurios anksčiau buvo nežinomos. Šio straipsnio tikslas – priminti senas ir aprašyti naujas streptokokinės infekcijos komplikacijas, remiantis Vaikų ligoninėje, VšĮ Vilniaus universiteto ligoninės Santariškių klinikų filiale gydytų ligonių atvejais. Tyrimo medžiaga ir metodai. Klinikinių atvejų aprašymas ir literatūros apžvalga. Rezultatai. Aprašomi trys Vaikų ligoninėje gydyti vaikai, kuriems diagnozuotos itin sunkios streptokokinės kilmės sisteminės ir vietinės komplikacijos. Pirmuoju atveju berniukui praėjus 2 savaitėms po ūminio tonzilito diagnozuotas parafaringinis abscesas ir glomerulonefritas. Antruoju atveju mergaitei, kuriai anksčiau buvo diagnozuotas febrilinis artritas, pakartotinai sukarščiavus, aptiktas sunkus reumatinės kilmės širdies pažeidimas, kuriam prireikė chirurginio gydymo. Trečiasis aprašytasis atvejis – mergaitės, kuriai nustatyta mažai žinoma, naujai aprašyta komplikacija PANDAS sindromas. Išvados. Ūminis tonzilitas vaikams yra dažna ir daugeliu atvejų nesunki liga, tačiau A grupės beta hemolizinio streptokoko sukeltas tonzilitas privalo būti gydomas antibiotikais, nes tik tokiu būdu galima išvengti daugelio vietinių ir sisteminių komplikacijų. Komplikacijos šiais laikais retos, tačiau pasitaiko, o kai kuriais atvejais – ir kelios vienu metu. Todėl gydytojai privalo neprarasti budrumo jas diagnozuodami ir laiku pradėti gydyti.

Airn, materials and methods: To find gender-related differences in blood pressure (BP) and urinary chloride excretion as well as a relation between them, we monitored diurnal, overnight, and 24-h urinary chloride as well as BP hourly in 22 adolescent males and 22 adolescent females. To show a possible influence of sexual honnones on chloride excretion and BP. we also tnonitored 15 adolescent females during different phases of their menstrual cycle. Results: The overnight systolic and pulse BP was significantly higher in males than in females. The diurnal pulse BP was significantly higher in tnales than in females at the beginning of follicular phase. The diurnal systolic, diastolic, and mean BP was significantly higher than nocturnal in all tbe groups studied. The overnight urinary chloride level in fctnales at the beginning of the follicular phase was significantly lower than during ovulation. Urinary chloride level during kiteal phase was comparable with that during ovulation. The total 24-h urinary chloride in the general group of males was signi ficantly h igher than in females at the beginning of follicular phase. In the general -group of fetnales, diurnal urinary chloride exeretion negatively correlated with diastolic and mean BP, but such a correlation was absent in males. Overnight, on the contrary, the correlation between urinary chloride excretion and [JP was absent in fetnales, but it was positive in tnales. The diurnal and overnight urinary chloride excretion exhibited a negative correlation with BP in females during luteal phase. A correlation between overnight chloride excretion and tncan BP was positive in tnales, but negative in females during luteal phase. Conclusion: BP, urinary chloride exeretion, and relation between them in adolescents are gender-and circadian cyclerelated. Sexual honnones tnay play a role botb in regulation of BP and urinary ehloride excretion.