With the continuous development of deep learning based medical image segmentation technology, it is expected to attain more robust and accurate performance for more challenging tasks, such as multi-organs, small/irregular areas, and ambiguous boundary issues. Methods: We propose a variance-aware attention U-Net to solve the problem of multi-organ segmentation. Specifically, a simple yet effective variancebased uncertainty mechanism is devised to evaluate the discrimination of each voxel via its prediction probability. The proposed variance uncertainty is further embedded into an attention architecture, which not only aggregates multi-level deep features in a global-level but also enforces the network to pay extra attention to voxels with uncertain predictions during training. Results: Extensive experiments on challenging abdominal multi-organ CT dataset show that our proposed method consistently outperforms cutting-edge attention networks with respect to the evaluation metrics of Dice index (DSC), 95% Hausdorff distance (95HD) and average symmetric surface distance (ASSD). Conclusions:The proposed network provides an accurate and robust solution for multi-organ segmentation and has the potential to be used for improving other segmentation applications.

Herpes zoster (HZ) can cause a blistering skin rash with severe neuropathic pain. Pharmacotherapy is the most common treatment for HZ patients. However, most patients are usually the elderly or those that are immunocompromised, and thus often suffer from side effects or easily get intractable post-herpetic neuralgia (PHN) if medication fails. It is challenging for clinicians to tailor treatment to patients, due to the lack of prognosis information on the neurological pathogenesis that underlies HZ. In the current study, we aimed at characterizing the brain structural pattern of HZ before treatment with medication that could help predict medication responses. High-resolution structural magnetic resonance imaging (MRI) scans of 14 right-handed HZ patients (aged 61.0 ± 7.0, 8 males) with poor response and 15 (aged 62.6 ± 8.3, 5 males) age- ( p = 0.58), gender-matched ( p = 0.20) patients responding well, were acquired and analyzed. Multivoxel pattern analysis (MVPA) with a searchlight algorithm and support vector machine (SVM), was applied to identify the spatial pattern of the gray matter (GM) volume, with high predicting accuracy. The predictive regions, with an accuracy higher than 79%, were located within the cerebellum, posterior insular cortex (pIC), middle and orbital frontal lobes (mFC and OFC), anterior and middle cingulum (ACC and MCC), precuneus (PCu) and cuneus. Among these regions, mFC, pIC and MCC displayed significant increases of GM volumes in patients with poor response, compared to those with a good response. The combination of sMRI and MVPA might be a useful tool to explore the neuroanatomical imaging biomarkers of HZ-related pain associated with medication responses.

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