Background Breast cancer is the second most common causes of women’s death, worldwide. Data on risk factors associated with female breast cancer in the Afghan population is very limited. The aim of our study was to identifying risk factor associated with female breast cancer in Afghanistan. Methods A retrospective case-control study was conducted with inclusion of 201 cases and 201 controls. Patient information was collected by interviewing the patient through a structured questionnaire. Histopathological information was collected from the hospital integrated laboratory management system. The data was analyzed by using logistic regression with univariate and multivariable analyses to determine the association between breast cancer and predictors. Results The results of the current study showed that factors such as: age (OR = 1.02; 95%CI: 0.99–1.04; p-0.148); age at menarche (OR = 0.83; 95%CI: 0.72–0.92; p-0.008); age at first baby (OR = 1.14; 95%CI: 1.07–1.20; p- < 0.001); illiteracy (OR = 1.93; 95%CI: 1.16–3.22; p-0.011); smoking (OR = 2.01; 95%CI: 1.01–3.99; p-0.04) and family history of cancer (OR = 1.98; 95%CI: 1.18–3.32; p-0.009) were significantly associated with breast cancer. However, our study did not demonstrate any statistically significant correlation between breast cancer and some of the predictors that were previously highlighted in literature, such as: marital status, Body Mass Index (BMI), use of hormonal contraceptive, breastfeeding and exercise. Conclusion Our study demonstrated that age at menarche, and age at first baby birth, illiteracy, smoking and family history of cancer were significant risk factors associated with development of breast cancer among women in Afghanistan. Health education of women regarding aforementioned predisposing factors are therefore, expected to be valuable in decreasing the burden of breast cancer with reduction of its burden on the healthcare system in Afghanistan.

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Introduction: Fibroadenoma (FA) in ectopic male breast tissue is extremely rare. The ectopic breast tissue (EBT) is mostly appearing along the milk line; however, uncommon locations are also seen, such as the present case. Case Presentation: The authors report a 19-year-old male presenting with intestinal obstruction. The patient underwent laparoscopic surgery, and an excisional biopsy of the lesion was done. The histopathologic result confirms FA arising from EBT. This case is reported for its rarity. It indicates that FA should always be considered when there is an intra-abdominal suspicious mass. Discussion: EBT presenting as FA is also reported in the face, posterior neck, chest, middle back, buttocks, vulvar, and thighs. In this case, the authors present a EBT presented as a FA in the intra-abdomen of a young male patient, causing intestinal obstruction. FA in the male breast is rare; however, benign breast parenchyma showing FA in the intra-abdomen of a male patient is extremely rare. Conclusion: When a tumor is palpated in the milk line, the existence of FA should be taken into consideration. FA of the male EBT in the intra-abdomen is extremely rare. However, a close follow-up of the patient is strongly recommended, as the carcinoma arising from FA has a very poor prognosis.

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