Pilomatricoma (PM; calcifying epithelioma of Malherbe) is a benign tumor originating from the matrix of the hair follicles. Clinical types of the tumor are familial, perforating, multinodular, exophytic, anetodermic, and giant PM. The bullous type is seen only in 3 to 6% of cases. Because the bullous areas detected in PM are filled with lymphatic liquid, some authors use the term pseudobulla. This report presents a 26-year-old female patient that was diagnosed with pseudobullous PM based on clinical, radiologic, and histopathological findings, and the pathogenesis of the bullous appearance of PM is reviewed from the literature.

Fox-Fordyce Disease (FFD) is a rare, chronic, pruritic, inflammatory disorder of apocrine glands. It is characterized by dome-shaped, firm, discrete, skin-colored, and monomorphic perifollicular papules. The most common sites of involvement are axillae and anogenital and periareolar regions which are rich in apocrine sweat glands. Treatment is difficult. Topical, intralesional steroids, topical tretinoin, adapalene, clindamycin, benzoyl peroxide, oral contraceptives, isotretinoin, phototherapy, electrocauterisation, excision-liposuction and curettage, and fractional carbon dioxide laser are among the treatment options. In the literature, there are articles reporting beneficial effects of pimecrolimus in FFD. Nevertheless, there have not been any reports about the use of tacrolimus in FFD. We report two patients diagnosed with FFD by clinical and histopathologic examination and discussed therapeutic effects of topical tacrolimus on FFD in the light of literature.

Idiopathic scrotal calcinosis (ISC) is an uncommon benign process, characterized by solitary or multiple, painless, strict scrotal nodules in the lack of systemic metabolic disorder. Its nature and reason have remained unknown and theories of origin contain idiopathic calcification arising within normal scrotal collagen, dystrophic calcification of inflamed scrotal epidermoid cysts, eccrine duct milia or dartoic muscle, and secondary to minor trauma. A total of 5 cases were found for ISC in our department of pathology. All patients underwent surgical excision of the lesions with overlying skin. Age range was from 25 to 49 years with a mean age of 31.4 years. Three of the patients with multiple lesions (3/5). The common appearance of the masses were hard, slowly growing, semi-mobile, lobulated, and well-circumscribed subcutaneous nodules. Diameter of the lesions ranged 0.7cm to 3cm. Grossly, there were firm, white with chalky and gritty areas. H&E stains revealed basophilic masses in dermis with foreign body giant cell reaction in 4 cases. No recurrences were noted. ISC is a rare, benign, disease of the scrotal skin that is characterized by calcium depositions of various sizes surrounded by a granulomatous reaction. In spite of the debate about the origin of this entity, surgery still seems to be the treatment of option and provides a good clinical outcome.

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