Introduction: Candida albicans are normal flora bacteria on the skin and mucous membranes of humans. Candida albicans are said to be one of the causes of vaginal discharge or fluor albus. Temu kunci (Boesenbergia pandurata (Roxb.) Schlect) and temulawak (Curcuma xanthorrhiza Roxb) are the ingredients of herbal medicines with the potential as an antifungal. Purpose: This study aims to explain the differences in the antifungal effect of the Temu kunci (Boesenbergia pandurata (Roxb.) Schlect) and Temulawak (Curcuma xanthorrhiza Roxb) extracts and explain how the combination of Temu kunci (Boesenbergia pandurata (Roxb.) Schlect) and Temulawak (Curcuma xanthorrhiza Roxb) extracts has an antifungal effect on Candida albicans by using the experimental study of post-test control group design. Method: This study uses the Kirby-Baurer method and then measures the inhibitory zone by using calipers then comparing the inhibition zone of each extract. Results: The research results show no difference in the effectiveness of each extract, and no inhibition zone was found for each extract. Conclusion: This study concludes that the two extracts are not effective against C.albicans.

Introduction : Pharyngitis is one of the most common infection that general practitioners handled. It is estimated in one year there are 15 million people with pharyngitis will come to the doctor. American Society of Microbiology said that 94,3 % from 402 patient who were suspected pharyngitis received antibiotic therapy even without indication of antibiotic therapy. Antibiotic resistance is becoming a great threat for the world today. World Health Organization state that one of the plan to fight antibiotic resistance is to research and develop new drugs. Curcuma domestica is a plant that is widely used in Indonesia and some research said that it has anti-inflammatory, antioxidant, and antimicrobial effect. Aim: The aim of this study is to find the antibacterial effect of Curcuma domestica ethanolic extract on Group A Streptococcus β hemolyticus and find the Minimum Bactericidal Concentration (MBC) value. Methods : This was in vitro experimental study with broth microdilution method and inoculation on agar blood media to find the MBC. Treatment group consisting of, media (Mueller Hinton Blood Broth), Group A Streptococcus β hemolyticus bacteria, and 5 concentrations (312.5 µg/ml, 625 µg/ml, 1250 µg/ml, 2500 µg/ml, 5000 µg/ml) of Curcuma domestica extract. Result : There is no bacterial growth at 5000 µg/ml concentration on solid media, but there are less bacterial growth at 2500 µg/ml than at concentration 312.5 µg/ml, 625 µg/ml, 1250 µg/ml. Conclusion: There is an antibacterial effect of Curcuma domestica ethanolic extract on Group A Streptococcus β hemolyticus with MBC value in range 2500 -5000 µg/ml.

Introduction:The age of an infant is an essential age for growth. Its development is highspeed, follows a particular pattern, and varies between individual. An infant is still vulnerable to various health problems. The infant's development will be optimal if the mother's knowledge level is right and appropriate social interaction with the needs of the baby at its development stage. Purpose: This study aims to analyze the relationship between mother's knowledge levels about growth development with the compatibility of growing development in infants aged 6-12 months. Method: This study used an observational analytic method with a cross-sectional design. Statistical analysis used the Chi-Square test to determine the correlation followed by a contingency coefficient. Samples were taken according to the criteria of age 6-12 months as much as 55 respondents. data on the mother's knowledge level was collected using a questionnaire. The research evaluate growth using a baby scale of height, weight, head circumference, and to evaluate development progress using a prescreening developmental questionnaire (KPSP). This study was conducted on July 5 -August 1, 2019, at the Gotong Royong Pratama Clinic in Surabaya. Results:The relationship of mother's knowledge level about growth development with the compatibility of growing development in infants aged 6-12 months obtained significant results with a p-value of p = 0,000 (p <0.05). Contingency coefficient test results with a value of 0.436 which shows that the strength of the relationship is strong enough. the relationship between mother's knowledge level about growing development with the compatibility of growing development in infants aged 6-12 months obtained significant results with a p-value of p = 0.007 (p <0.05 ). Contingency coefficient test results with a value of 0,343, which shows that the strength of the relationship is strong enough. Conclusion:There is a significant relationship between the mother's knowledge levels about growing development with the compatibility of growing development in infants aged 6-12 months.

Objective: The aim of this study is to prove the relationship of FcγRI (CD64) expression and Procalcitonin value in earlyonset neonatal sepsis to assist in diagnosis of early-onset neonatal sepsis. Method: A descriptive and analytical case control study was conducted in dr. Saiful Anwar General Hospital Malang. There were 40 children divided into two groups: 1). Group of infants with neonatal risk factors who express signs of SIRS and proven by blood culture; 2). Group of infants with neonatal risk factors who showed no sign for SIRS. Both groups were performed examination of FcγRI (CD64) expression with flowcytometry and Procalcitonin value with ELISA. Data were statistically analyzed using normality test (Kolmogorov-Smirnov), chi square test, t test and Pearson correlation. We used SPSS 16 for this analysis. Results: The study showed that the FcγRI (CD64) expression and Procalcitonin value were higher in the infants group with proven early-onset neonatal sepsis (p less than 0.05). There was a significant relationship between FcγRI (CD64) expression and the Procalcitonin value (p=0.036). Conclusions: We conclude that expression of FcγRI (CD64) and Procalcitonin value were higher in the infants group with proven early-onset neonatal sepsis. There is a positive relationship between FcγRI (CD64) expression and Procalcitonin value in early onset neonatal sepsis