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Commercially available oral rinses, containing chlorhexidine are effective in treating and preventing oral infections but they can cause unpleasant taste and staining of teeth and are not advocated for long- term oral care. Hence comes the need for an alternative remedy with reduced side effects that is suitable for daily regime. Coleus blumei has been reported to contain phytochemicals that are active against oral bacteria. The objective of this study is to determine the phytochemicals content of C. blumei leaves extract and its potential as an antibacterial agent to treat oral infection as alternative to chlorhexidine. C. blumei extract was first screened for its phytochemicals content and was later screened for its antibacterial activity against Staphylococcus aureus and Streptococcus mitis using disc diffusion method. The extract was tested to find the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for both bacteria. The phytochemicals screenings showed that the extract contains flavonoid, terpenoid, tannin and saponin. At a concentration of 100 mg/ml, the extract showed antibacterial activity against both bacteria, S. aureus (14.56 mm) and S. mitis (13 mm), with Percentage of Relative Inhibition Zone Diameter (% RIZD) of 35% (S. aureus) and 65% (S. mitis). The extract was shown to have similar effects as Oradex oral rinse (0.12% chlorhexidine), with 15.67 mm inhibition zone and % RIZD of 38% for S. aureus, and 15mm with % RIZD of 75% for S. mitis. The MIC results shows that the extract was most effective against S. aureus, as the MIC was determined at the lowest concentration of 1.5625 mg/ml and the MBC was determine at the concentration of 100 mg, 50 mg/ml, 25 mg/ml, 12.5 mg/ml, 6.25 mg/ml and 3.125 mg/ml. For S. mitis, the MIC was determined at the concentration of 25 mg/ml, with MBC value at the highest concentration of 100 mg/ml. These results suggest that C. blumei extract possesses antibacterial effects against oral bacteria similar to Oradex and therefore has the potential to be used as an oral rinse in the future.

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Background: A correct tridimensional implant placement requires a sufficient amount of bone to completely satisfy the prosthetic reconstruction. Several techniques can be used to recreate the bone quantity. Among them, titanium meshes have shown great potential in space maintenance and fewer complications in case of exposure. Recently, 3D CAD, CAM technology, and specifically SLM have been used to produce customized meshes in titanium alloy. The aim Purpose of this systematic review is to evaluate new customized meshes compared to traditional ones in terms of new volume of generated bone and the incidence of complications. Materials and Methods: A MEDLINE/PubMed literature search was performed to find relevant randomized controlled clinical trials published in English up to and including December 2022. The Cochrane Database of Systematic Reviews and SCOPUS were also searched. The main keywords used in the search were: titanium meshe(s), customized titanium meshe(s), combined with AND/OR as Boolean operators, and bone augmentation with/and/or titanium mesh. Results: The electronic search identified 1002 papers in total, and after duplicate removal, 500 articles were screened. After a manual screening of the title and abstract, 488 studies were excluded, and 12 articles' full text of 12 articles was analyzed. Further analysis was performed to make sure that the articles matched the inclusion/exclusion criteria of the present review. Six additional articles were excluded in this phase. No meta-analysis was performed due to the heterogeneity of the data. Conclusion: By using traditional or customized devices with the newly generated bone volume allowed the implant placement in all cases. Complications were mainly reported as exposure during the healing phase, but the conclusions of whether customized or conventional systems perform one better than the other are still inconclusive.