The aim of this study is to evaluate the changes in intraocular pressure (IOP), central corneal thickness (CCT), and retinal nerve fiber layer thickness (RNFLT) in patients with chronic renal failure undergoing hemodialysis (HD). A complete ophthalmological examination together with IOP, CCT, and RNFLT measurements were performed for each patient both before and after HD sessions. RNFLT parameters were detected by scanning laser polarimeter. Total body weight and serum osmolality were also measured. Only the left eyes were recruited for statistical analysis. Thirty-three eyes of 33 patients were enrolled in the study. Mean IOP decreased from 14.7 +/- 3.1 to 13.4 +/- 2.4 mmHg after HD (paired t test, P = 0.005). Mean CCT also decreased significantly after HD, from 556.5 +/- 33.5 to 550.2 +/- 34.6 mum (paired t test, P = 0.002). CCT change in the left eyes was found to be correlated with total body volume loss (Pearson correlation test, R = 0.391 and P = 0.030). Considering RNFLT parameters before and after HD, no significant alterations were detected by scanning laser polarimeter (paired t test, P > 0.05). We conclude that IOP may decrease to some extent after HD. CCT may be affected by fluid loss after HD sessions, with a resultant decrease in corneal thickness. In patients with chronic renal failure undergoing HD, RNFLT parameters can be measured as in healthy individuals. Underestimation of intraocular pressure values after HD sessions should be taken into account, especially in patients with chronic renal failure.

Dry eye and irritational symptoms are major ocular symptoms in CRF patients. Serum calcium and phosphate levels seem to have a prognostic importance for the ocular findings and symptoms in patients with CRF.

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Large-area MMC application seems to increase long-term success without increasing the complication rates in trabeculectomy.

Précis: The present study demonstrates that surgical success rate of gonioscopy-assisted transluminal trabeculotomy (GATT) is 83.7% according to target intraocular pressure (IOP) ≤21 mm Hg and ≥20% reduction from baseline in patients with moderate to advanced glaucoma, with an average follow-up of 19.4 months. Purpose: The aim of the study was to assess the outcomes of GATT in eyes with moderate to advanced open-angle glaucoma. Patients and Methods: A retrospective study included 104 eyes of 104 patients, with a mean age of 58.9±18.5 (15 to 87) years, who underwent GATT using the 6/0 prolene suture to treat open-angle glaucoma. The GATT procedure was carried out alone or in combination with phacoemulsification. IOP at baseline, third, sixth, ninth, 12th, and 18th months of follow-up; need of antiglaucoma medication; need of further glaucoma surgery; cup/disc ratio; and best-corrected visual acuity (BCVA) were recorded. Patients with prior incisional glaucoma surgery were excluded. Surgical success was determined for both IOP <21 and <18 mm Hg and also ≥20% reduction from baseline without further glaucoma surgery. Results: A total of 65 patients with primary open-angle glaucoma (POAG) and 39 patients with secondary open-angle glaucoma (SOAG), including pseudoexfoliative, pigmentary, uveitic, and steroid-induced glaucoma underwent GATT. Preoperative mean IOP was 25.0±7.3 mm Hg. Preoperative average number of antiglaucoma medications was 3.4±0.6. The average follow-up time was 19.4±8.1 (6 to 37) months. Preoperative average BCVA was 0.51±0.24, and cup/disc ratio was 0.85±0.14. Surgical success was achieved in 87 of 104 (83.7%). Seven patients had medically uncontrolled glaucoma after GATT surgery, and they underwent further surgery. Patients with POAG had a higher percentage of IOP reduction than patients with SOAG at 18th month of follow-up (40.1% vs. 27.6%). Need for medication at final visit was similar between POAG and SOAG. Conclusion: GATT procedure is a safe and successful option for the treatment of moderate to advanced open-angle glaucoma. Surgical success could be maintained up to ∼18 months.