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Objectives: Thyroid hormone has effects on cardiovascular system other than metabolism. This study aimed to investigate the association between thyroid hormone and Arterial stiffness (AS) in type 2 diabetes mellitus (T2DM). Methods: 1064 T2DM patients were included in the cross-sectional study. They were divided into two groups: AS group (baPWV≥1550cm/s) and Non-AS group (baPWV<1550cm/s) or PAD group (ABI≤0.9)or Non-PAD group(ABI>0.9). Results: 1) FT3, FT4, TT3 and TT4 were comparable (all P>0.05) while TSH were significantly higher in PAD group than Non-PAD group(2.19±1.86μIU/mL vs. 1.85±1.95μIU/mL, P=0.031). FT3 was significantly lower while TSH was significantly higher in AS group than Non-AS group (4.52±0.74 pmol/L vs.4.72±1.45pmol/L, P=0.007; 2.28±2.03μIU/mL vs.1.95±1.38μIU/mL, P=0.009). FT4, TT3 and TT4 had no difference between the two groups. 2) ABI was significantly positively associated with TT3(r=0.091, P=0.006) while baPWV was significantly negatively associated with TT3 and FT3(r=-0.065, P=0.049; r=-0.149, P<0.001). Multiple linear regression showed that FT3 were the negatively influencing factor of baPWV (β=-75.24, P<0.001). 3) baPWV was significantly higher in patients with subclinical hypothyroidism than without subclinical hypothyroidism (1831.11±347.39 cm/s vs.1729.32±377.12, P=0.027). 4) Logistic regression showed that FT3 was protective factor of AS assessed by baPWV (OR:0.708, 95% CI: 0.506-0.990, P=0.044). Conclusions: T2DM patients with Arterial stiffness defined by ABI or baPWV have higher TSH and lower FT3 while baPWV was higher in patients with subclinical hypothyroidism. FT3 was negatively influencing factor of baPWV and protective factor of AS assessed by baPWV. Disclosure Y. Chen: None. Z. Hong: None. B. Ma: None. X. Wang: None. S. Qu: None. Funding National Natural Science Foundation of China (81970677)

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ObjectiveThis study aimed to investigate the effect of left ventricular aneurysm (LVA) volume and left ventricular global torsion on cardiac function by real time three-dimensional echocardiography (RT-3DE) and two-dimensional speckle tracking imaging(2D-STI), to determine the accuracy of RT-3DE and 2D-STI in assessing LV function.MethodsThirty New Zealand rabbit models of with LVA were prepared by ligation of the middle segment of the left anterior descending and left circumflex arteries. Four weeks post-procedure, RT-3DE was conducted to obtain data on LVEF, left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), and LVA volume (LVAV), Peak rotation angles at the mitral valve annulus level (MV-ROT), peak rotation angles at the apical level (AP-ROT), and left ventricular global torsion angles (LV-TOR) were measured by 2D-STI.ResultsCompared with controls, LVEDV and LVESV were significantly increased in the LVA group, while LVEF, MV-ROT, AP-ROT, and LV-TOR were consistently reduced (p<0.01). Moreover, LVEF correlated with LVA volume and LV torsion angle (r= -0.778 and 0.821, p<0.01). LVA volume/LVEDV had the strongest inverse relationship with LVEF (r= -0.911, p<0.01).ConclusionLVA volume, LVA volume/LVEDV, and LV torsion may be used as an indicator for evaluation of cardiac function after LVA. Moreover, LVA volume/LVEDV may be a more sensitive and reliable marker of cardiac function after LVA formation.