The objective of this study was to identify potential biomarkers and possible metabolic pathways of malignant and benign thyroid nodules through lipidomics study. A total of 47 papillary thyroid carcinomas (PTC) and 33 control check (CK) were enrolled. Plasma samples were collected for UPLC-Q-TOF MS system detection, and then OPLS-DA model was used to identify differential metabolites. Based on classical statistical methods and machine learning, potential biomarkers were characterized and related metabolic pathways were identified. According to the metabolic spectrum, 13 metabolites were identified between PTC group and CK group, and a total of five metabolites were obtained after further screening. Its metabolic pathways were involved in glycerophospholipid metabolism, linoleic acid metabolism, alpha-linolenic acid metabolism, glycosylphosphatidylinositol (GPI)—anchor biosynthesis, Phosphatidylinositol signaling system and the metabolism of arachidonic acid metabolism. The metabolomics method based on PROTON nuclear magnetic resonance (NMR) had great potential for distinguishing normal subjects from PTC. GlcCer(d14:1/24:1), PE-NME (18:1/18:1), SM(d16:1/24:1), SM(d18:1/15:0), and SM(d18:1/16:1) can be used as potential serum markers for the diagnosis of PTC.

Our results reveal that six specific lipids could serve as potential biomarkers for early diagnosis of breast cancer.

No abstract

No abstract

Biometallic materials are widely used in medicine because of excellent mechanical properties. However, biometallic materials are limited in the application of biomaterials due to their lack of bioactivity. To solve this problem, a gradient bioceramic coating doped with diatomite (DE) was successfully fabricated on the surface of Ti6Al4V alloy by using the broadband-laser cladding process to improve the bioactivity of metal materials. As well as the DE contents on the microstructure, microhardness, bioactivity and biocompatibility were investigated. The experimental results demonstrate that the addition of moderate amounts of DE is effective in reducing the number of cracks. The X-ray diffraction (XRD) results reveal that the bioceramic coating doped with DE mainly consists of CaTiO3, hydroxyapatite (HA), tricalcium phosphate (TCP) and silicate, and that the amount of HA and TCP in the coating reached maximum when the bioceramic coating was doped with 10wt% DE. The bioceramic coating doped with 10wt% DE has favorable ability to deposit bone-like apatite. These results indicate that the addition of DE can improve cracking sensibility, bioactivity and biocompatibility of the coating.