The China–Mongolia border region contains many late Mesozoic extensional basins that together constitute a regionally extensive basin system. Individual basins within the system are internally composed of a family of sub‐basins filled with relatively thin sedimentary piles mostly less than 5 km in thickness. There are two types of sub‐basins within the basins, failed and combined, respectively. The failed sub‐basins are those that failed to continue developing with time. In contrast, the combined ones are those that succeeded in growing by coalescing adjacent previously isolated sub‐basins. Thus, a combined sub‐basin is bounded by a linked through‐going normal fault that usually displays a corrugated trace on map view and a shallower dip on cross‐section. Along‐strike existence of discrete depocenters and alternation of sedimentary wedges of different types validate the linkage origin of combined sub‐basins. Localized high‐strain extension resulted in large‐amount displacement on linked faults, but contemporaneously brought about the cessation of some isolated fault segments and the formation of corresponding failed sub‐basins in intervening areas between active linked faults. Some combined sub‐basins might have evolved into supradetachment basins through time, concurrent with rapid denudation of footwall rocks and formation of metamorphic core complexes in places. A tectonic scenario of the broad basin system can be envisioned as an evolution from early‐stage distributed isolated sub‐basins to late‐stage focused combined or/and supradetachment sub‐basins bounded by linked faults, accompanied by synchronous cessation of some early‐formed sub‐basins. Initiation of the late Mesozoic extension is believed to result from gravitational collapse of the crust that had been overthickened shortly prior to the extension. Compression, arising from collision of Siberia and the amalgamated North China–Mongolia block along the Mongol–Okhotsk suture in the time interval from the Middle to Late Jurassic, led to significant shortening and thickening over a broad area and subsequent extensional collapse. Pre‐ and syn‐extensional voluminous magmatism must have considerably reduced the viscosity of the overthickened crust, thereby not only facilitating the gravitational collapse but enabling the lower‐middle crust to flow as well. Flow of a thicker crustal layer is assumed to have occurred coevally with upper‐crustal stretching so as to diminish the potential contrast of crustal thickness by repositioning materials from less extended to highly extending regions. Lateral middle‐ and lower‐crustal flow and its resultant upward push upon the upper crust provide a satisfying explanation for a number of unusual phenomena, such as supracrustal activity of the extension, absence or negligibleness of postrift subsidence of the basin system, less reduction of crustal thickness after extension, and non‐compression‐induced basin inversion, all of which have been paradoxical in the previous study of the late Mesozoic basin tectonics in...

Mesenchymal stem cells (MSCs) have been increasingly applied into clinical therapy. Exosomes are small (30–100 nm in diameter) membrane vesicles released by different cell types and possess the similar functions with their derived cells. Human umbilical cord MSC-derived exosomes (hucMSC-Ex) play important roles in liver repair. However, the effects and mechanisms of hucMSC-Ex on liver injury development remain elusive. Mouse models of acute and chronic liver injury and liver tumor were induced by carbon tetrachloride (CCl4) injection, followed by administration of hucMSC-Ex via the tail vein. Alleviation of liver injury by hucMSC-Ex was determined. We further explored the production of oxidative stress and apoptosis in the development of liver injury and compared the antioxidant effects of hucMSC-Ex with frequently used hepatic protectant, bifendate (DDB) in liver injury. hucMSC-Ex alleviated CCl4-induced acute liver injury and liver fibrosis and restrained the growth of liver tumors. Decreased oxidative stress and apoptosis were found in hucMSC-Ex-treated mouse models and liver cells. Compared to bifendate (DDB) treatment, hucMSC-Ex presented more distinct antioxidant and hepatoprotective effects. hucMSC-Ex may suppress CCl4-induced liver injury development via antioxidant potentials and could be a more effective antioxidant than DDB in CCl4-induced liver tumor development.

Olivine-hosted melt inclusions within lava retain information regarding the lava"s primary magma compositions and mantle sources. Thus, they can be used to infer the nature of the mantle sources of large igneous provinces, which is still not well known and of the subject of debate. We have analyzed the chemical compositions and Pb isotopic ratios of olivine-hosted melt inclusions in the Dali picrites, Emeishan Large Igneous Province (LIP), SW China. These are the first in-situ Pb isotope data measured for melt inclusions found in the Emeishan picrites and allow new constraints to be placed on the source lithology of the Emeishan LIP. The melt inclusions show chemical compositional variations, spanning low-, intermediate-and high-Ti compositions, while their host whole rocks are restricted to the intermediate-Ti compositions. Together with the relatively constant Pb isotope ratios of the melt inclusions, the compositional variations suggest that the low-, intermediate-and high-Ti melts were derived from compositionally similar sources. The geochemical characteristics of melt inclusions, their host olivines, and whole-rocks from the Emeishan LIP indicate that Ca, Al, Mn, Yb, and Lu behave compatibly, and Ti, Rb, Sr, Zr, and Nb behave incompatibly during partial melting, requiring a pyroxenite source for the Emeishin LIP. The wide range of Ti contents in the melt inclusions and whole-rocks of the Emeishan basalts reflects different degrees of partial melting in the pyroxenite source at different depths in the melting column. The Pb isotope compositions of the melt inclusions and the OIB-like trace element compositions of the Emeishan basalts imply that mixing of a recycled ancient oceanic crust (EM1-like) component with a peridotite component from the lower mantle (FOZO-like component) could have underwent solid-state reaction, producing a secondary pyroxenite source that was subsequently partially melted to form the basalts. This new model of pyroxenite melting could explain the geochemical variations among the low-, intermediate-and high-Ti basalts for the Emeishan LIP and challenges the prevailing belief that the source of the Emeishan basalts is peridotite- .

Based on the latest conventional-unconventional oil and gas databases and relevant reports, the distribution features of global tight oil were analyzed.

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