Optimization-based algorithms for image reconstruction in multi-spectral (or photon-counting) computed tomography (MCT) remains a topic of active research. The challenge of optimization-based image reconstruction in MCT stems from the inherently non-linear data model that can lead to a non-convex optimization program for which no mathematically exact solver seems to exist for achieving globally optimal solutions. In the work, based upon a non-linear data model, we design a non-convex optimization program, derive its first-order-optimality conditions, and propose an algorithm to solve the program for image reconstruction in MCT. In addition to consideration of image reconstruction for standard scan configuration, an emphasis of the work is on investigating the algorithm’s potential for enabling non-standard scan configurations with no or minimum hardware modification to existing CT systems, which can be of potential practical implications for lowered hardware cost, enhanced scanning flexibility, and reduced imaging dose/time in MCT. Numerical studies are carried out for verification of the algorithm and its implementation, and for a preliminary demonstration and characterization of the algorithm in reconstructing images and in enabling non-standard configurations with varying scanning angular range and/or X-ray illumination coverage in MCT.

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We investigate an optimization-based reconstruction, with an emphasis on image-artifact reduction, from data collected in C-arm cone-beam computed tomography (CBCT) employed in image-guided interventional procedures. In the study, an image to be reconstructed is formulated as a solution to a convex optimization program in which a weighted data divergence is minimized subject to a constraint on the image total variation (TV); a data-derivative fidelity is introduced in the program specifically for effectively suppressing dominant, low-frequency data artifact caused by, e.g., data truncation; and the Chambolle-Pock (CP) algorithm is tailored to reconstruct an image through solving the program. Like any other reconstructions, the optimization-based reconstruction considered depends upon numerous parameters. We elucidate the parameters, illustrate their determination, and demonstrate their impact on the reconstruction. The optimization-based reconstruction, when applied to data collected from swine and patient subjects, yields images with visibly reduced artifacts in contrast to the reference reconstruction, and it also appears to exhibit a high degree of robustness against distinctively different anatomies of imaged subjects and scanning conditions of clinical significance. Knowledge and insights gained in the study may be exploited for aiding in the design of practical reconstructions of truly clinical-application utility.

We propose a novel structured discriminative blockdiagonal dictionary learning method, referred to as scalable Locality-Constrained Projective Dictionary Learning (LC-PDL), for efficient representation and classification. To improve the scalability by saving both training and testing time, our LC-PDL aims at learning a structured discriminative dictionary and a block-diagonal representation without using costly l 0 /l 1 -norm. Besides, it avoids extra time-consuming sparse reconstruction process with the well-trained dictionary for new sample as many existing models. More importantly, LC-PDL avoids using the complementary data matrix to learn the sub-dictionary over each class. To enhance the performance, we incorporate a locality constraint of atoms into the DL procedures to keep local information and obtain the codes of samples over each class separately. A block-diagonal discriminative approximation term is also derived to learn a discriminative projection to bridge data with their codes by extracting the special block-diagonal features from data, which can ensure the approximate coefficients to associate with its label information clearly. Then, a robust multiclass classifier is trained over extracted block-diagonal codes for accurate label predictions. Experimental results verify the effectiveness of our algorithm.