(tripartite motif-containing 27) was originally identified as a fusion partner with the RET (REarranged during transfection) proto-oncogene and is highly expressed in various tumor cells and tissues. However, the level of expression and function of TRIM27 in ovarian cancer remain unclear. Here we have measured the expression of TRIM27 in normal ovarian and fallopian tube epithelial cells and in ovarian serous carcinoma cells and correlated TRIM27 expression with clinical and pathological parameters. In addition, we detected the effect of TRIM27 knockdown on proliferation of ovarian cancer cells in cell culture and xenografts. The results demonstrated that TRIM27 was highly expressed in ovarian serous carcinoma cells, and TRIM27 expression was significantly correlated with metastasis and FIGO stage in ovarian serous carcinoma patients. Downregulation of TRIM27 expression suppressed the proliferation of ovarian cancer cells in cell culture and inhibited the growth of xenografts in nude mice. TRIM27 knockdown induced cell cycle arrest and apoptosis in ovarian cancer cells by upregulating the expression of p-P38 and downregulating the expression of p-AKT. Thus the present study suggests that TRIM27 could have important roles as an oncogene during the development of ovarian cancer and could serve as a diagnostic and therapeutic target.

Tree peony (Paeonia Sect. Moutan) is a famous ornamental plant, with huge historical, cultural, and economic significance worldwide. In this study, we reported the ~13.79 Gb draft genome of a wide‐grown Paeonia suffruticosa cultivar “Luo shen xiao chun,” representing the largest sequenced genome in dicots to date. Phylogenetic analyses based on genome sequences demonstrated that P. suffruticosa was placed as sister to Vitales, and they together formed a clade that was sister to Rosids, weakly supporting a relationship of ((Saxifragales and Vitales) and Rosids). The identification and expression analysis of MADS‐box genes based on the genome assembly and de novo transcriptome assembly of P. suffruticosa revealed that the function of C class genes was restricted in flower development, which might be responsible for the stamen petalody in tree peony cultivars. Overall, the first sequenced genome in the family Paeoniaceae provides an important resource for the origin, domestication, and evolutionary study as well as cultivar breeding in tree peony.

Activated carbon is a promising sorbent for adsorption removal of polycyclic aromatic hydrocarbons (PAHs) because of its cost effectiveness. The desorption kinetics of two-ring PAHs, naphthalene and acenaphthene, over bituminous coal-based (AC WY ) and coconut shell-based (AC NT ) activated carbons were investigated. The desorption kinetics were studied over the temperature range of 400800 K at different heating rates (820 K/min) using thermogravimetric analysis techniques. The activation energy, pre-exponential factor and the kinetic model for each sorbate-sorbent pair were determined by applying analytical methods to the non-isothermal data. The Johnson-Mehl-Avrami (JMA) rate equation, g(α) = [ln(1-α)] n (in integral form, where α is fractional completion), following the nucleation and growth model was found to best describe the PAHs desorption from both sorbents. Strong molecular sieving effects were found to influence both adsorption capacity and desorption rates. AC WY , with less micropore (< 0.7 nm) volume and more larger pores (0.72 nm) compared to AC NT , favors PAHs adsorption and desorption rates, leading to different values of kinetic exponent (n) and other kinetic parameters. Likewise, the sieving effects favor adsorption and desorption of naphthalene (kinetic diameter: 0.62 nm) over acenaphthene (0.66 nm) for both carbons.

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