These results imply that fish consumption was associated with a reduced risk of all-cause mortality.

ABSTRACT.We investigated a possible association between genetic variations in the thiazide-sensitive Na-Cl cotransporter (TSC) gene and essential hypertension (EH) in the Mongolian and Han ethnic groups in Inner Mongolia. Our study included 385 unrelated Mongolian herdsmen and 523 Han farmers. Nine tagSNPs of TSC were identified from the Chinese HapMap database based on pairwise r 2 ≥ 0.5 and minor allele frequency ≥0.05. Genotyping was performed using the PCR/ligase detection reaction assay. Association between tagSNPs and hypertension was investigated under the additive model. There were significant differences between the genotype and allele frequencies of rs13306673 between the EH group and the control group in the Han population. Significant associations were found between the rs7204044 variant and EH in both the Mongolian and Han ethnic groups. The frequency of haplotype GCA in the EH group was significantly higher than in the control group in the Mongolian population. In the Han population, the frequency of haplotype TGG was significantly higher in the EH group than in controls, whereas haplotype TGA occurred significantly less often in EH than in controls. We suggest that rs7204044 of TSC is a TSC gene variants and hypertension in Mongolian genetic factor for EH in these two ethnicities and that rs13306673 is a genetic factor for EH in the Han population.

Type 2 diabetes is a disease caused by genetic and environmental factors that endanger public health [1]. At present, hereditary factors are still unknown, and it has been confirmed that type 2 diabetes is closely related to a highcalorie diet, lack of exercise, obesity, etc. [2,3]. It has been reported that the overall incidence of diabetes in Chinese adults is about 11.6%, and the prediabetes incidence in these people is 50.1%. However, the awareness rate of