The effect of Schisandra chinensis extract (SCE) on the learning and memory ability of mice with learning and memory disorders was investigated. After mice were given SCE prophylactically, different methods were used to establish mouse learning and memory disorders, and the radial maze test was used for the observation of SCE on the learning and memory ability of mice with learning and memory disorders. A mouse aging model was established by subcutaneously injecting d-galactose. The antiaging, antifatigue, and antioxidant effects of SCE were evaluated by weight change, the loaded swimming test, and changes in total antioxidant capacity and superoxide dismutase (SOD) levels in the serum and brain of mice. The result showed that SCE could significantly improve the learning and memory behavior of mice with learning and memory disorders induced by scopolamine, chloramphenicol, and 40% ethanol, respectively, maintain normal weight gain, prolong the loaded swimming time, improve the antioxidant capacity, and increase the activity of SOD in the serum and brain of aging mice. SCE can significantly improve the learning and memory ability of mice with learning and memory disorders, which may be related to its antioxidant effect.