Convenient synthesis
and useful application of a series of Josiphos-type
binaphane ligands were described. The iridium complexes of these chiral
diphosphines displayed excellent enantioselectivity and good reactivity
in the asymmetric hydrogenation of challenging 1-aryl-substituted
dihydroisoquinoline substrates (full conversions, up to >99% ee, 4000 TON). The use of 40% HBr (aqueous solution) as
an additive dramatically improved the asymmetric induction of these
catalysts. This transformation provided a highly efficient and enantioselective
access to chiral 1-aryl-substituted tetrahydroisoquinolines, which
were of great importance and common in natural products and biologically
active molecules.
As a cross-cutting and comprehensive
subject, medicinal chemistry
involves the knowledge of chemical, biological, medical, and pharmaceutical
sciences. A comprehensive medicinal chemistry experience for undergraduates
is expected to train various experimental skills and enhance their
scientific research ability. Herein, a series of laboratory and computational
experiments performed by undergraduate students were described, including
synthesis, acetylation, and activity testing of an acetylcholinesterase
inhibitor, tacrine. The inhibition activities of tacrine and acetylated
tacrine were discussed based on the results of computer simulations.
Moreover, representative student-generated data, methods of the experiments,
and an interpretation of student feedback on the project are presented.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.