Excess ultraviolet (UV) radiation causes numerous forms of skin damage. The aim of the present study was to assess and compare the photoprotective effects of cyanidin-3- O-glucoside (C3G) alone and encapsulated in chitosan nanoparticles (Nano-C3G) in a UVB-induced acute photodamage mouse model. Nano-C3G was developed from chitosan and sodium tripolyphosphate (TPP) by ionic gelation. The particle size, zeta potential, entrapment efficiency, drug loading, and in vitro release in 6 days were determined. Kunming (KM) mice were treated with Nano-C3G (125, 250, 500 μM) or C3G (500 μM) after part of the dorsal skin area was dehaired and then exposed to 2 J/cm of UVB. The nanocapsules were successfully produced and had a uniform and complete spherical shape without agglomeration. The size, zeta potential, entrapment efficiency, and drug loading of Nano-C3G was 288 nm, +30 mV, 44.90%, and 4.30%, respectively. C3G in the nanocapsules was released quite rapidly, and the release rate slowed down at higher pH. The animal experiment demonstrated that Nano-C3G could effectively reduce the UVB-induced lipid peroxidation, malondialdehyde, and 8-hydroxy-2'-deoxyguanosine contents; downregulate p53, Bcl-2-associated X (Bax), and caspase-3 and -9 expression; and balance the B-cell lymphoma-2/leukemia-2 ratio. Moreover, Nano-C3G (125, 250, 500 μM) improved the visual appearance, skin moisture, histologic appearance, and apoptotic index (based on TUNEL staining) under UVB exposure. In conclusion, these results suggest that Nano-C3G can reduce UVB-induced epidermal damage through the p53-mediated apoptosis signaling pathway. Moreover, Nano-C3G was more efficient than C3G at the same concentration (500 μM).

This paper presents a flexible microstrip low-pass filter (LPF) fabricated on a polyimide film substrate. The proposed flexible microstrip LPF with ten cascaded asymmetrical Pi-shaped defected ground structure (DGS) resonators are designed, simulated, manufactured, and measured. The simulation and experiment results demonstrate that the designed flexible microstrip LPF has a very sharp transition band, an ultra-wide stop-band (SB) and high rejection in SB performance compared with the existed microstrip LPFs with symmetrical and asymmetrical DGS. The proposed flexible LPF with ten cascaded resonators is with a compact size of 100 mm × 2.6 mm × 0.254 mm, a very low insertion loss of less than 1.9 dB under 2.2 GHz, and a wide SB from 2.7 to 12 GHz with the rejection of larger than 50 dB. The proposed flexible LPF has the potential to be used in wireless terminals to replace the traditional RF coaxial cable because it is very thin and has good transmission and filtering functions.INDEX TERMS Defected ground structure (DGS), flexible printed circuit board (FPCB), low-pass filter (LPF), pi-shaped DGS, wireless communication.

By using a simple and universal process, we successfully synthesized various sulfonated porous organic polymers with high proton conductivity, and therefore this strategy could evolve structural designs for high proton-conductive materials.

Two-dimensional covalent organic frameworks (2D COFs) have attracted much attentions in proton conduction, owing to their regular pore channels and easy functionalization. However, most of COFs required the loading of...

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