This review introduces the recent advance in the construction of MOF-based sensing platforms in chemical sensing and biosensing. In particular, the fabricating strategies of MOF-based luminescent sensors and the sensing mechanisms are reviewed.

Gold nanoclusters (AuNCs), with sizes of less than 2 nm, consist of several to hundreds of gold atoms. Protected by templates or ligands, AuNCs not only have high and chemical...

Nanoscale metal−organic frameworks (NMOFs) have been proved to be effective quenching platforms for fluorescent detection of DNA via fluorophorequencher pairs. Zeolitic imidazolate framework-8 (ZIF-8) is one type of the most promising NMOFs because of its excellent biocompatibility and easy preparation. However, ZIF-8 is rarely used as platforms for fluorescence sensing of DNA because of its bad fluorescence quenching property. In this study, lanthanide ions were doped into ZIF-8 to regulate its fluorescence quenching behavior. The La 3+ doped ZIF-8 (ZIF-8-La) showed the best quenching efficiency on dyelabeled DNA. The signal-to-background ratio was around 3 times higher than ZIF-8. Furthermore, a core−shell La 3+ -doped ZIF-8 (CS-ZIF-8-La) was designed to modify more La 3+ on the surface of ZIF-8. Compared with ZIF-8-La, the CS-ZIF-8-La exhibited the same fluorescence sensing behavior toward positivedye-labeled DNA, but showed completely contrary quenching property on the negative-dye-labeled DNA. On the basis of this phenomenon, CS-ZIF-8-La was successfully used as quenching platform for designing a ratiometric sensor for DNA and microRNA.

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A novel nanoarchitecture (MSN-Tb-UbR) was prepared by modifying rhodamine B-labelled Ubs (Ub-Rs) on the surface of mesoporous silica nanoparticles (MSNs) loaded with Tb3+-complexes.