Objective. To study the effect of CICARE (Connect, Introduce, Communicate, Ask, Respond, Exit) communication mode on disease uncertainty, self-nursing ability, and quality of life in patients with coronary atherosclerotic heart disease (CAD) after percutaneous coronary intervention (PCI). Methods. From January 2021 to December 2021, 102 patients with CAD after PCI were randomly divided into a research group ( n  =51) and a control group ( n  =51). The former received CICARE communication model nursing intervention, and the latter received routine doctor-patient communication nursing. To study the scores of disease uncertainty scale (MUIS), Frankl treatment compliance scale (Frankl), self-care ability scale (exercise of self-care-a), quality of life scale (WHOQOL-BREF), and Newcastle nursing satisfaction scale (NSNS) before and 1 week after nursing. Results. After one week of nursing, the MUIS score of the research group was lower than that of the control group, and the score of Frankl treatment compliance scale of the research group was higher than that of the control group. After 1 week of nursing, the ESCA score of the research group was higher compared to the control group ( p < 0.05 ), and the WHOQOL-BREF score of the research group was higher compared to the control group ( p < 0.05 ). After one week of nursing, the NSNS score of the research group was higher compared to the control group ( p < 0.05 ). Conclusion. The application value of CICARE communication mode nursing intervention in patients with CAD after PCI is more remarkable, and it is more helpful to reduce patients’ disease uncertainty, enhance treatment compliance, promote patients’ self-nursing ability, and strengthen quality of life and nursing satisfaction.