Surface-enhanced Raman scattering (SERS) as a label-free, non-contact, highly sensitive, and powerful technique has been widely applied in determining bio- and chemical molecules with fingerprint recognitions. 2-dimensional (2D) materials with layered structures, tunable optical properties, good chemical/physical stabilities, and strong charge–transfer interaction with molecules have attracted researchers’ interests. Two-D materials with a large and flat surface area, as well as good biocompatibility have been considered promising candidates in SERS and widely applied in chemical and bio-applications. It is well known that the noble metallic nanostructures with localized surface plasmon effects dominate the SERS performance. The combination of noble metallic nanostructure with 2D materials is becoming a new and attractive research domain. Until now, the SERS substrates combined with 2D materials, such as 2D graphene/metallic NPs, 2D materials@metallic core-shell structures, and metallic structure/2D materials/metallic structure are intensely studied. In this review, we introduce different kinds of fabrication strategies of 2D and 3D SERS substrates combing with 2D materials as well as their applications. We hope this review will help readers to figure out new ideas in designing and fabricating SERS substrates with high SERS performance that could enlarge the applicable domains of SERS.

Biosensors based on surface techniques, combined with the advantage of physical/chemical mechanisms, demonstrate great potential in detecting Covid-19/SARS-CoV-2.

We study a cost effective and easy way to fabricate stable, uniform and large area surface-enhanced Raman scattering (SERS) substrates. The AgNPs with varying diameters have been fabricated through a thermally treating method on SiO2/Si substrate which present a high sensitivity, good uniformity and good stability. By using rhodamine 6G (R6G) molecule as analyte, the maximized detection limit is as low as 10−8 M. The deviation of SERS intensity by using proposed AgNPs SERS substrate is less than 15% which indicates its good uniformity. This work provides an efficiently way of fabricating industry SERS substrates which are good candidate in practical application in medicine, food safety and biotechnology.

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