ObjectivesTo compare the diagnostic efficacy of SonoVue-enhanced and Sonazoid-enhanced ultrasound (US) for hepatocellular carcinoma (HCC) in patients at high risk.MethodsBetween August 2021 and February 2022, participants at high risk for HCC with focal liver lesions were enrolled and underwent both SonoVue- and Sonazoid-enhanced US. Vascular-phase and Kupffer phase (KP) imaging features of contrast-enhanced US (CEUS) were analyzed. The diagnostic performance of both contrast agent-enhanced US according to the CEUS liver imaging reporting and data system (LI-RADS) and the modified criteria (using KP defect instead of late and mild washout) were compared. Histopathology and contrast-enhanced MRI/CT were used as reference standards.ResultsIn total, 62 nodules, namely, 55 HCCs, 3 non-HCC malignancies and 4 hemangiomas, from 59 participants were included. SonoVue-enhanced US had comparable sensitivity to Sonazoid-enhanced US for diagnosing HCC [80% (95% confidential interval (CI): 67%, 89.6%) versus 74.6% (95% CI: 61%, 85.3%), p = 0.25]. Both SonoVue and Sonazoid-enhanced US achieved a specificity of 100%. Compared with CEUS LI-RADS, the modified criteria with Sonazoid did not improve sensitivity for HCC diagnosis [74.6% (95% CI: 61%, 85.3%) versus 76.4% (95% CI: 63%, 86.8%), p = 0.99].ConclusionsSonazoid-enhanced US had comparable diagnostic performance to SonoVue-enhanced US for patients with HCC risk. KP did not considerably improve the diagnostic efficacy, whereas KP defects in atypical hemangioma may be pitfalls in diagnosing HCC. Further studies with larger sample sizes are needed to further validate the conclusions in the present study.

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Pancreatic neurofibroma is a very rare benign neurogenic tumor unrelated to neurofibromatosis type 1 (NF-1). As the volume increases, it has the risk of malignant transformation. The surgical prognosis of pancreatic neurofibroma is good, but its preoperative imaging features are very similar to those of malignant tumors, which may affect the formulation of treatment plans. This article reports a case of giant neurofibroma of the pancreas with contrast-enhanced ultrasound (CEUS) as one of the diagnostic methods and discusses the tumor’s preoperative clinical features, laboratory examinations, and imaging features.

When a working face is crossing the abandoned roadways, problems such as roof subsidence, rock fracture, and instability will occur, resulting in widespread roof fall and rib spalling, which seriously affect safe and efficient mining on the working face. In this paper, the no. 23 coal pillar working face of Juji coal mine is taken as the engineering background, a mechanical model of crossing the abandoned roadways is constructed aimed at the problem of the working face crossing the abandoned roadway group, the collapse of the abandoned roadway roof is analyzed, a scheme of crossing the abandoned roadways is designed, and the development law of the stress and plastic zone after the reinforcement scheme is stimulated and analyzed. The results show that when the working face advances to the abandoned roadway, key block B crosses the abandoned roadway and the solid coal to form a “cross-roadway long key block.” It is calculated that the minimum support resistance required for the abandoned roadway is 6700 kN. Based on the results of numerical comparison, it is concluded that filling wood pile when the working face passes through the roof abandoned roadway and adding anchor cables for reinforcement support when the working face crosses the coal seam abandoned roadway effectively reduce the stress concentration of surrounding rocks, decrease the development of the plastic zone, and achieve safe and efficient mining when the working face crosses the abandoned roadways.