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This paper provides a very efficient, integrated framework for seismic analyses of long-span cable-stayed bridges. The efficiency comes from the dramatic reduction in formation time and the degrees of freedom (DOF) associated with the structure, using the integrated finite strip method (IFSM) along with the application of a very robust and efficient time history method (THM) using the Newmark scheme for dynamic analysis of the bridge structure. The previous versions of the finite strip method are limited to modeling the bridge deck only, whereas other structural components are replaced by assumed boundary conditions. Using the IFSM, all components of the long-span cable-stayed bridge can be modeled in a unified system, and consequently, the real dynamic behavior including the interactions between deck, piers, and cables can be perfectly considered. To verify the solution, the geometric and dynamic properties of the Kap Shui Mun (KSM) Bridge, as a real example of a long-span cable-stayed bridge, are derived by the proposed finite strip method. Then, the seismic response of KSM Bridge under uniform and nonuniform earthquake loadings is investigated by using the THM. The results show that the IFSM can be applied successfully for seismic analysis of long-span cable-stayed bridges, and the analysis can be performed in a minimal amount of time.

IntroductionEmergence delirium (ED) is a common adverse manifestation after general anaesthesia and may result in undesirable consequences. Its causes and mechanisms are diverse and complex, and it is still unavoidable in clinical work. There is a high incidence of ED after otorhinolaryngology surgery, which may result from the sudden loss of functional senses and discomfort of surgical organs. This study aims to test a non-invasive, non-drug treatment modality of nose clamping and mouth-breathing training before surgery to reduce ED.Methods and analysisThis prospective randomised controlled trial (RCT) will include 200 patients who undergo functional endoscopic sinus surgery (FESS) at Shanghai General Hospital, China. Study participants will be randomly assigned in two groups with a 1:1 ratio. The pretreatment group (P-group) will receive an intervention by nasal splint and mouth-breathing training before surgery, while the control group (C-group) will not receive any intervention; following which both groups will undergo FESS under general anaesthesia in accordance with the same anaesthesia scheme. After surgery, we will perform a single-blinded assessment of ED occurrence with stratification. IBM SPSS Statistics V.20 statistical software will be used for statistical analyses. A X2 test will be used to compare the two groups, and t-tests will determine the statistical significance of continuous variables.Ethics and disseminationThis RCT was designed in accordance with the principles of the Declaration of Helsinki and has been approved by the Ethics Committee of Shanghai General Hospital, ID: 2019KY039.We expect to release the original data in February 2022 on the ResMan original data sharing platform (IPD sharing platform) of the China clinical trial registry, which can be viewed at the following website:http://www.medresman.org.cn/pub/cn/proj/projectshow.aspx?proj=6293.Trial registration numberChiCTR1900024925