Purpose: To generate and evaluate individualized post-therapeutic optical coherence tomography (OCT) images that could predict the short-term response of anti-vascular endothelial growth factor (VEGF) therapy for diabetic macular edema (DME) based on pre-therapeutic images using generative adversarial network (GAN). Methods: Real-world imaging data were collected at the Department of Ophthalmology, Qilu Hospital. A total of 561 pairs of pre-therapeutic and post-therapeutic OCT images of patients with DME were retrospectively included in the training set, 71 pre-therapeutic OCT images were included in the validation set, and their corresponding post-therapeutic OCT images were used to evaluate the synthetic images. A pix2pixHD method was adopted to predict post-therapeutic OCT images in DME patients that received anti-VEGF therapy. The quality and similarity of synthetic OCT images were evaluated independently by a screening experiment and an evaluation experiment. Results: The post-therapeutic OCT images generated by the GAN model based on big data were comparable to the actual images, and the response of edema resorption was also close to the ground truth. Most synthetic images (65/71) were difficult to differentiate from the actual OCT images by retinal specialists. The mean absolute error (MAE) of the central macular thickness (CMT) between the synthetic OCT images and the actual images was 24.51 ± 18.56 μm. Conclusions: The application of GAN can objectively demonstrate the individual short-term response of anti-VEGF therapy one month in advance based on OCT images with high accuracy, which could potentially help to improve treatment compliance of DME patients, identify patients who are not responding well to treatment and optimize the treatment program.

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Purpose: To investigate whether the FCVB could help improve the mental health of patients with impending eye atrophy. Methods: Fifty-five patients who underwent FCVB implantation from 2017 to 2019 were screened to take part in this retrospective study. The researchers used independent third parties to distribute questionnaires, including the Hospital Anxiety and Depression Scale and the interpersonal sensitivity part of the Symptom Checklist 90 (SCL-90) scale to score the patients' depression, anxiety, and interpersonal sensitivity before and after surgery. Finally, 52 responses were collected.Results: After FCVB implantation, patients had significantly better mental health and less depression, anxiety, and interpersonal sensitivity levels. Before FCVB implantation, 44.23% of patients with ocular trauma and retinal detachment were depressed, 48.08% were anxious, and 19.23% were sensitive to interpersonal communication. After FCVB implantation, 17.31% were depressed, 15.38% were anxious, and 9.62% were sensitive to interpersonal communication. However, baseline demographic and clinical data, such as age, gender, occupation, finance, pre-FCVB-implantation vision, number of surgeries before FCVB implantation, postoperative period length, and surgical satisfaction, had no significant effects on psychological scores of mental health before and after surgery (P> 0.05). Conclusion: Mental health (depression, anxiety, and interpersonal sensitivity) significantly improved in patients after FCVB implantation.

Purpose: To investigate whether the FCVB could help improve the mental health of patients with impending eye atrophy. Methods: Fifty-five patients who underwent FCVB implantation from 2017 to 2019 were screened to take part in this retrospective study. The researchers used independent third parties to distribute questionnaires, including the Hospital Anxiety and Depression Scale and the interpersonal sensitivity part of the Symptom Checklist 90 (SCL-90) scale to score the patients' depression, anxiety, and interpersonal sensitivity before and after surgery. Finally, 52 responses were collected.Results: After FCVB implantation, patients had significantly better mental health and less depression, anxiety, and interpersonal sensitivity levels. Before FCVB implantation, 44.23% of patients with ocular trauma and retinal detachment were depressed, 48.08% were anxious, and 19.23% were sensitive to interpersonal communication. After FCVB implantation, 17.31% were depressed, 15.38% were anxious, and 9.62% were sensitive to interpersonal communication. However, baseline demographic and clinical data, such as age, gender, occupation, finance, pre-FCVB-implantation vision, number of surgeries before FCVB implantation, postoperative period length, and surgical satisfaction, had no significant effects on psychological scores of mental health before and after surgery (P> 0.05). Conclusion: Mental health (depression, anxiety, and interpersonal sensitivity) significantly improved in patients after FCVB implantation.