The electromagnetic behavior of a microwave sensor has specific relationship with the physical properties of the materials to be detected, e.g., the concentration of solution and the permittivity of gas. The microwave sensor can detect changes of EM response in real time, and obtain the material properties with low sample consumption, high efficiency and dispersion characteristics. This work presents a microfluidic sensor using spiral resonators and plasmonic metamaterials with confined electromagnetic fields for intensive resonance. Two microfluidic chips with spiral channels engraved in polydimethylsiloxane (PDMS) are also adopted to enhance the interaction between the electromagnetic fields and the carried liquids at resonance frequencies. The permittivity of liquid samples can be detected through the shift of resonance frequency. A prototype of the sensor is fabricated and tested with several regular solutions and organic solvents, showing a good performance in terms of low liquid consumption (8 μL), good sensitivity (410 MHz frequency offset when εr changes from 1 to 36.7) and low cost
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