Highlights People with positive SARS-CoV-2 RNA of respiratory tract specimen are infectious source of COVID-19. SARS-CoV-2 RNA of respiratory tract specimen may be persistent or recurrent positive during the course. Dynamic surveillance of SARS-CoV-2 RNA should be performed for infectivity assessment. AbstractThe ongoing outbreak of COVID-19 that began in Wuhan, China, has constituted a Public Health Emergency of International Concern, with cases confirmed in multiple countries. Currently patients are the main source of infection. We report a confirmed case of COVID-19 whose oropharyngeal swab test of SARS-CoV-2 RNA turned positive in convalescence. This case highlights the J o u r n a l P r e -p r o o f 2 importance of dynamic surveillance of SARS-CoV-2 RNA for infectivity assessment.

Highlights d Mitochondria-located circRNA SCAR inhibits mROS output and fibroblast activation d circRNA SCAR shuts down mPTP by binding to ATP5B d Lipid-induced ER stress impairs PGC-1a-mediated circRNA SCAR expression d Mitochondria-specific delivery of circRNA SCAR alleviates metaflammation in vivo

Intelligent skinlike materials have recently attracted tremendous research interests for employing in electronic skin, soft robotics, and wearable devices. Because the traditional soft matters are restricted in unsatisfactory mechanical performances or short-term usage, these materials are adverse to practical applications. Here, intriguing conductive hydrogel materials with multifunctionality (MFHs) are fabricated by using poly­(acrylic acid) (PAA), dopamine-functionalized hyaluronic acid (DHA), and Fe3+ as ionic cross-linker. The mussel-inspired networks with delicate combination of physical and chemical cross-linking possess synergistic features of inherent viscoelasticity, high stretchability (800%), and durable self-adhesiveness to various substrates. Owing to the abundant hydrogen bonds and multiple metal coordination interactions between Fe3+, catechol, and carboxylic groups, the matrix reveals repeatable thermoplasticity and autonomous self-healing property both mechanically and electrically (98% recovery in 2 s). When served as strain sensors, the MFHs can distinctly perceive complex body motions from tiny physiological signal (breathing) to large movements (knee bending) as human motion detecting devices. Moreover, the MFHs were explored as ideal material for circuit repairing, programming, and switches constructing because of their excellent properties. Consequently, these eco-friendly hydrogel ionotronic devices can be promising candidates for next-generation intelligent wearable devices and human–machine interfaces.

No abstract