Data from 753 earthquakes are used to determine a relationship between surface-wave magnitude (Ms) and bodywave magnitude (rob), and from 541 earthquakes to determine a relationship between surface-wave magnitude (Ms) and local magnitude (ML) for China and vicinity: Ms= 0.9883 rob-0.0420, Ms=0.9919 ML-0.1773. The relationship ofM s versus m b is obtained for 292 events occurred in the Chinese mainland in the time period from 1964 to 1996, 291 events occurred in Taiwan in the time period from 1964 to 1995 and 170 events occurred in the surrounding area. Standard deviation of the fitting is 0.445. Relationship ofM s versus M L is obtained for 36 events occurred in the Chinese mainland, 293 events occurred in Taiwan, China and 212 events occurred in the surrounding area. The total amount is 541 events. Standard deviation of the fitting is 0.4673.The uncertainties of the converted M s in different magnitude intervals can be estimated using complementary cumulative distribution function (CCDF). In the relationship of M s versus mb, taking +0.25 as a range of uncertainties, in magnitude interval m b 4.0-4.9, the probabilities for the converted M s taken value less than (Ms-0.25) and more than (Ms+0.25) are 17% and 27% respectively. Similarly, we have probabilities for m b 5.0-5.9 are 34% and 20% and that for m b 6.0-6.9 are 11% and 47%.In the relationship of M s versus ML, if the range of uncertainties is still taken as +0.25, the corresponding probabilities for magnitude interval ML 4.0-4.9 are 22% and 38%, for M L 5.0-5.9 are 20% and 15% and for magnitude interval M L 6.0-6.9, are 15% and 29%, respectively.The relationships developed in this paper can be used for the conversion of one magnitude scale into another magnitude scales conveniently. The estimation of uncertainties described in this paper is more accurate and more objective than the usual estimation expressed by deviation. The estimations described in this paper indicate various dispersions in different magnitude intervals of original data. The estimations of uncertainties described by probabilities can be well connected with the total estimations of uncertainties in seismic hazard assessment.

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Approximately 50% of patients with tuberous sclerosis complex (TSC) present intractable epilepsy, and surgery is an option for those patients. Hereby, we analyze long-term seizure control and neuropsychological outcomes of epilepsy surgery in patients with TSC. Clinical data were retrospectively collected from 66 patients with TSC and epilepsy followed up over 5 years, 51 of whom underwent epilepsy surgery between 2001 and 2011. Reductions in the number of seizures were analyzed at 1-year (1FU), 5-year (5FU), and 10-year (10FU) follow-ups visits after the operation. Influential factors on postoperative seizure free and intelligence quotient (IQ) and quality-of-life (QOL) outcomes were evaluated at 5FU. Resective procedures included 26 tuber resections, 15 lobectomies, and 10 tuber resections and lobectomies. Corpus callosotomies were performed as the adjunctive approach in 11 cases with low IQ. The percentages of seizure-free cases were 74.5% at 1FU, 58.8% at 5FU, and 47.8% at 10FU, and the predictive factor for long-term postoperative seizure freedom was the history of preoperative seizures and preoperative full-scale IQ. Significant improvements were found in performance IQ, full-scale IQ, and QOL in patients from the surgery group, particularly those who were seizure free after the operation. Our study showed that epilepsy surgery in TSC with epilepsy rendered improvements in seizure control, full-scale IQ, and QOL. Satisfactory long-term seizure control was often achieved with an early operation and without mental retardation, and improvements in QOL and IQ were frequently observed in postoperative patients who remained seizure free.

CSNK2B, which encodes the beta subunit of casein kinase II (CK2), plays an important role in neuron morphology and synaptic transmission. Variants in CSNK2B associated with epilepsy and/or intellectual disability (ID)/developmental delay (DD) have been reported in five cases only. Among the 816 probands suspected hereditary epilepsy whose initial report of trio-based whole exome sequencing (WES) were negative, 10 de novo pathogenic or likely pathogenic variants of CSNK2B in nine probands were identified after reanalysis of their raw Trio-WES data. Six of the nine epileptic patients had ID/DD. The age of seizure onset of these nine patients with CSNK2B variants ranged from 2–12 months. Eight patients had age of seizure onset of less than 6 months. The epilepsy of most probands (8/9) was generalized tonic-clonic seizure and clustered (6/9). Most patients had normal electroencephalogram (5/9) and brain magnetic resonance image (7/9) results. Most patients (7/9) had easy-to-control seizures. Levetiracetam was the most commonly used drug in seizure-free patients (5/7). The variants detected in five patients (5/9, 55.6%) were located in the zinc-binding domain. In summary, our research provided evidence that variants in CSNK2B are associated with epilepsy with or without ID/DD. CSNK2B-related epilepsy is relatively easy to be controlled. The zinc-binding domain appears to be the hotspot region for mutation.

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