Obstacle aquatic therapy in this protocol seems to be more effective than traditional protocols for gait and balance in patients with Parkinson's disease, and the effect lasts for six months.

The results of this study suggest that a relatively short programme (four weeks) of hydrotherapy exercise resulted in a large improvement in a small group (n = 14) of individuals with relatively high balance and walking function following a stroke.

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PurposeForkhead box K2 (FOXK2) is a member of the forkhead box family of transcription factors. Recently, researchers discovered that overexpression of FOXK2 inhibits the proliferation and metastasis of breast cancer, non-small cell lung cancer, and colorectal cancer, and is related to the clinical prognosis. However, in hepatocellular carcinoma, FOXK2 results in the opposite phenotypes. Currently, the contribution of FOXK2 to glioma pathogenesis is not clear.Patients and methodsWe evaluated the expression of FOXK2 in 151 glioma patients using immunohistochemistry assays. The associations among the expression of FOXK2, clinicopathological parameters, and the prognosis of glioma patients were statistically analyzed. We downregulated and upregulated the level of FOXK2 in glioma cells by transfections with small interfering RNA and plasmids. Then, we investigated the effects on tumor cell behavior in vitro by Cell Counting Kit-8 assays, colony-formation assay, transwell assay, and the epithelial-to-mesenchymal transition (EMT) biomarker levels.ResultsThe clinical data showed that expression of FOXK2 gradually decreased with increasing World Health Organization (WHO) grades and a low level of FOXK2 indicates a poor prognosis. FOXK2 expression is negatively correlated with Ki67 expression and the WHO degree but is not correlated with other clinicopathological parameters, including sex, age, Karnofsky Performance Status, tumor diameter, O-6-methylguanine-DNA methyltransferase, and glutathione S-transferase pi. FOXK2 knockdown enhances glioma cell proliferation, migration, invasion, and EMT process, and, in contrast, FOXK2 overexpression inhibits glioma cell proliferation, migration, invasion, and the EMT process.ConclusionExpression of FOXK2 gradually decreases with increasing WHO grades. FOXK2 inhibits tumor proliferation, migration, and invasion. FOXK2 is a critical mediator of the EMT process.

Fabric defect detection is very important in the textile quality process. Current deep learning algorithms are not effective in detecting tiny and extreme aspect ratio fabric defects. In this paper, we proposed a strong detection method, Priori Anchor Convolutional Neural Network (PRAN-Net), for fabric defect detection to improve the detection and location accuracy of fabric defects and decrease the inspection time. First, we used Feature Pyramid Network (FPN) by selected multi-scale feature maps to reserve more detailed information of tiny defects. Secondly, we proposed a trick to generate sparse priori anchors based on fabric defects ground truth boxes instead of fixed anchors to locate extreme defects more accurately and efficiently. Finally, a classification network is used to classify and refine the position of the fabric defects. The method was validated on two self-made fabric datasets. Experimental results indicate that our method significantly improved the accuracy and efficiency of detecting fabric defects and is more suitable to the automatic fabric defect detection.