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Dental implants with long‐term success of osseointegration have always been the goal, however, difficulties exist. The accumulation of fretting damage at the implant–bone interface often gets overlooked. Commonly used titanium is approximately 7‐fold harder and stiffer than cortical bone. Stress shielding caused by the mismatching of the elastic modulus aggravates fretting at the interface, which is accompanied by the risk of the formation of proinflammatory metal debris and implant loosening. Thus, the authors explore functionalized cortical bone‐inspired composites (FCBIC) with a hierarchical structure at multiple scales, that exhibit good mechanical and biological adaptivity with cortical bone. The design is inspired by nature, combining brittle minerals with organic molecules to maintain machinability, which helps to acquire excellent energy‐dissipating capability. It therefore has the comparable hardness and elastic modulus, strength, and elastic‐plastic deformation to cortical bone. Meanwhile, this cortical bone analogy exhibits excellent osteoinduction and osseointegration abilities. These two properties also facilitate each other to resist fretting wear, and therefore improve the success rate of implantation. Based on these results, the biological–mechanical co‐operation coefficient is proposed to describe the coupling between these two factors for designing the optimized dental implants.

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