Pregnancy luteoma is a rare condition of the ovary preceded by pregnancy. It is a distinctive, non-neoplastic lesion of the ovary. It is characterized by proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium. 1 It is associated with varied symptoms, for instance, hirsutism, acne, deepening of voice, and virilization. 2 The first case was reported by Sternberg and Barclay in 1966. To date, very few cases have been documented in the literature. 3 The Chinese and English reports are generally individual cases. We collected 18 cases with literature review to analyze their pathology and clinical characteristics so as to improve the pathology and clinician understanding of the disease.
Glioma is the most common central nervous system tumor with poor prognosis. The AEG-1 (Astrocyte Elevated Gene 1) gene displays oncogenic characteristics, including proliferation, metastasis, chemoresistance, invasion, and evasion of apoptosis, and is strongly linked to the occurrence of glioma. Here, we elucidated the potential contribution of AEG-1 in human glioma pathogenesis. In glioma cells, AEG-1 could directly interact with Murine Double Minute-2 (MDM2) protein resulting in MDM2-p53-mediated cell proliferation and apoptosis. MDM2 is being revealed as an oncoprotein, which is involved in many human cancers progression. By immunohistochemical and a multivariate analysis, expressions of AEG-1 and MDM2 were elevated in glioma and high AEG-1 and MDM2 expressions were showed to be correlated with poor prognosis. AEG-1-MDM2 interaction prolonged stabilization of MDM2 where AEG-1 inhibited ubiquitination and subsequent proteasome-mediated degradation of MDM2 protein. Moreover, slicing AEG-1 blocked MDM2 expression and then impacted MDM2-p53 pathway that influenced cell proliferation and apoptosis. These findings uncover a novel AEG-1-MDM2 interplay by which AEG-1 augments glioma progression and reveal a viable potential therapy for the treatment of glioma patients.
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