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In transdermal drug delivery systems, the physicochemical properties of the drug affect its percutaneous permeability. However, whether the physicochemical properties of drugs change their transdermal permeability in the presence of pores in the presence of solid microneedles (MNs) has been less studied in this area. In this project, cinnamaldehyde, curcumin, ferulic acid and geniposide were selected as model drugs for the study of their transdermal permeability under the action of MNs, and a combination of classical experiments and visualization means such as scanning electron microscopy and laser confocal was used to investigate the permeation-promoting mechanism of MNs. The results showed that the MNs had significant permeation-promoting effects on different properties of drugs, with the permeation-promoting effects on cinnamaldehyde, curcumin, ferulic acid and geniposide being 6.36, 17.43, 29.54 and 8.91 times, respectively, and the permeation-promoting effects were more pronounced for lipid-soluble and amphiphilic drugs. Using scanning electron microscopy, transmission electron microscopy and other means to confirm that MNs can promote the penetration by acting on the skin to produce pores, and their effect on skin structure is greater than that of drugs. In addition, the existence of pores increases the amount of drug transdermal, which may enhance the diffusion of drug on the skin, and has no effect on lipid exchange and transdermal route. Through the research, it has been found that MNs is equivalent to direct peeling of the stratum corneum (SC), but it is simpler and safer for the patient.

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This essay studies the knowledge investment coordinating mechanism of the core enterprise, which plays both the role of the platform innovation ecosystem manager and the role of knowledge investment in the cooperative product development in the platform innovation ecosystem. The study shows that the profit distributed to the core enterprise and the agent enterprises of the platform innovation ecosystem is positively correlated with the impact weight of their knowledge investment on the knowledge production value, i.e. the higher the impact weight is, the more profit they may gain, that the larger the number of the agent enterprises in the platform innovation ecosystem is, the higher level of knowledge investment effort the core enterprise will make, the larger the core enterprise's total gain will be, and that the higher the higher the knowledge coordination degree between the core enterprise and the agent enterprises is, the larger the core enterprise's total gain will be.