Introduction: While attending in university have pleasant experiences for many students, academic activities will lead to academic burnout for some of them. Obviously, academic burnout will have negative effects on mental, psychological and physical well-being of students. The purpose of this study was to determine the relationship between quality of learning experiences and academic burnout among nursing students of Shahid Beheshti University of Medical Sciences in 2015.Method: This descriptive-correlational study was conducted on 223 nursing students of Shahid Beheshti University of Medical Sciences in Tehran. The samples were selected by quota and then convenience sampling method, and demographic and educational questionnaires, Newman's quality of learning experience questionnaire and Bersow's academic burnout inventory were completed by subjects. Data were analyzed by descriptive and analytical methods such as correlation coefficient, independent t-test, one-way ANOVA and multiple linear regression. Results:The results showed a significant negative correlation between the quality of learning experiences and academic burnout (r = -0.18; p: 0.006), and the subscales of these two variables, with the most relationship was found between lack of academic interest and the content of the curriculum (r = -0.22; p: 0.001). By entering the main and underlying variables to multivariate linear regression model in step-by-step method, the student's interest in the field of study before entering the university and the mean score were known as the explanatory factor for academic burnout. Conclusion: Academic burnout of students can be influenced by the quality of their learning experiences. But this connection may indirectly be influenced by underlying factors such as academic performance and general interest in the field.