Background: To clarify the feasibility and efficacy of chemoradiotherapy (CRT) in elderly (age≥65 years) patients with locoregionally advanced nasopharyngeal carcinoma (NPC).

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The incidence of PPS involvement was 81.8%. The 5-year overall survival (OS), progression-free survival (PFS), distant metastasis-free survival (DMFS), and local relapse-free survival rates (LRFS) of the patients with and without PPS involvement were 68.1% and 90.2% (p = 0.010), 66.1% and 87.2% (p = 0.013), 76.7% and 93.6% (p = 0.032), and 84.9% and 93.1% (p = 0.220), respectively. Multivariate analysis showed that PPS involvement (yes vs no) was not an independent prognostic factor. However, graded PPS involvement was an independent factor affecting the prognosis of NPC. When the four classifications were included in a Cox model, it was shown that PPS involvement based on Min's classification was an independent factor for OS (p = 0.001). PPS involvement based on Sham's classification was an independent factor for PFS (p = 0.010) and DMFS (p = 0.009).

The DM group had higher EBV VCA-IgA titers than the control group (p = 0.017) and more acute adverse effects of RT (p < 0.001). No significant differences in the overall survival or late adverse effects were found between the two groups. Gender, TNM stage, and chemotherapy were independent prognostic factors for the overall survival in the DM group. No significant differences in the overall survival were found between the patients in the DM group who were taking glucocorticoids and those who were not.

Background: This study aimed to report our 10-year experiences on the treatment of recurrent Wilms tumor (WT) to improve the therapeutic outcome of recurrent WT in China. Patients and Methods: From August 2006 to August 2017, 14 patients (7 males and 7 females) with recurrent Wilms’ tumor treated at our center were included. Their medical records were reviewed. Results: Primary WT were mainly diagnosed at the age of 1-3 years (50%). The main histology of primary WT was unclassified types (42.9%), followed by blastemal types (35.7%). Four cases did not receive standardized postoperative chemotherapy after the initial surgery. Recurrence mostly occurred within the first year after initial surgery (57.1%). The recurrent WT mainly occurred at the primary location and ipsilateral lymph nodes (35.7%), followed by extensive peritoneal metastasis (28.6%). Eleven patients underwent surgery for complete resection of the recurrent lesions. There were 9 patients achieved event-free survival for 1 year 2 months to 9 years. Three, one, one and one patients died of extensive intraperitoneal metastases, brain metastasis, peritoneal metastasis, severe intestinal obstruction vomiting, electrolyte imbalance and tumor invasion of the spinal cord, respectively. Conclusions: Individualized multimodal treatment can effectively improve long-term survival of the patients of recurrence WT.