Against growing male infertility in the world, investigations are undertaken to find new bioactive molecules. Thus, the aim of this study was to evaluate the pharmacological effects of aqueous extract of Cnestis ferruginea on the reproductive parameters of male rats. Indeed, 36 male rats were divided into 2 groups of 18 each and treated for 30 days (set I) and 60 days (set II). Each set was subdivided into three groups. Group 1 (control) received distilled water. Groups 2 and 3 were treated with 50 (AECF 50 ) and 100 (AECF 100 ) mg/kg body weight of the aqueous extract of Cnestis ferruginea respectively. The results showed that extract induces significant increase in the wet Original Research Article

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Sarcocephalus latifolius is a popular medicinal plant used in treatment of many ailments basically in West Africa and particularly in Ivory Coast. Thereby, this study aims to find out the major chemical groups in the aqueous leaf extract of Sarcocephalus latifolius, its acute toxicity and its fertility potential. In this perspective, a phytochemical study to determine chemical groups was carried out. Furthermore, the acute oral toxicity study was conducted according to OECD guideline 423, using three female rats sequentially. As for the fertility study, it was performed on the histology of the testes of forty albino rats of 60 days of age weighing between 130 g and 170 g and treated for 30 and 60 days, at doses of 250; 500 and 1000 mg/kg body weight from the aqueous extract of Sarcocephalus latifolius. The phytochemical screaming of the aqueous leaf extract of Sarcocephalus latifolius revealed the presence of polyterpene sterols, polyphenols, flavonoids, quinonics and alkaloids. In addition, the acute oral toxicity assay did not reveal any signs of toxicity, morbidity or mortality at studied doses. Finally, the histology of testes of the albino rats treated with the plant extract showed a more intense spermatogenesis, seminiferous tubules and more developed interstitial tissue compared to control. To sum up Sarcocephalus latifolius, although rich in phytochemical compounds, might not be toxic in a single dose and might have androgenic effects.

Distemonanthus benthamianus est une plante utilisée en médecine traditionnelle dans certains pays Africains tels que : la Côte d’Ivoire, le Ghana, le Cameroun etc. Plusieurs études ont été réalisées relatives à son effet sur les activités antioxydante, antitumorale, antituberculeuse, bactéricide, antivirale. L’objectif de ce travail a été d’évaluer in vivo l’activité anti-inflammatoire de l’extrait total aqueux des écorces de cette plante. Pour atteindre cet objectif, le screening phytochimique a été réalisé afin de déterminer les métabolites secondaires présentent dans l’extrait de la plante. L’activité antiinflammatoire a été évalué par l’ingestion de la carragénine 1% au niveau l’aponévrose plantaire des rats Wistars. Le screening phytochimique a révélé la présence de tanins, polyphénols, flavonoïdes, saponosides, de triterpènes et d’alcaloïdes Les résultats de l’activité anti-inflammatoire ont montré que le diclofénac et l’extrait aqueux de la plante ont atteint leur activité maximale d’inhibition de l’œdème à la 3ème heure avec une inhibition de 52.88 %, et 44.95%, 60.03% et 70.19 aux doses de 200, 400 et 800mg/kg/pc respectivement. Quant à la prednisone, il a atteint son activité maximale de 26.66% à la 4ème heure. L’inhibition de l’œdème des pattes des rats par l’extrait de la plante montre ainsi les propriétés anti-inflammatoires de cet extrait. L’utilisation de cette plante comme un anti-inflammatoire en milieu naturel serait donc justifiée.

The objective of this work is to evaluate the fertilization and embryotoxic effects of aqueous extract of Cnestis ferruginea in rats. First, 3 batches of rats (control, treated AECF50 and AECF100) were mated with untreated males. Then, 3 batches of male rats (control, treated AECF50 and AECF100) were mated with untreated females. Finally, two groups of rats, I (males) and II (females) were subdivided into three batches each (control, treated AECF50 and AECF100) and were mated according to the dose. The results showed 100% gestation in the treated females, but an increase in the post-implantation abortion rate with the AECF100. Regarding the test of treated males, the pregnancy, copulation and fertility rates were 75%, 83.33% and 100% for controls, AECF50 and AECF100, respectively. Pre-and post-implantation abortion rates decreased with both doses. The test of treated males mated with the treated females showed a pregnancy rate, a copulation index, and a 100% fertility index compared to controls (83.33%). For the uterine, fetal and placental weights, the extract induced a significant increase in the treated females. Histological studies of the ovary showed a significant increase in the diameter of the corpus luteum (35.14%) and the diameter of the uterine glands by 16.05% (AECF50) and 18.39% (AECF100). In conclusion, Cnestis ferruginea improves fertility in males and females. But, these positive effects can be hindered by high doses.