Swivel bridge is a special construction method in bridge engineering. It has the characteristics of difficult construction, complex environment and many benefits. The project needs fine management to overcome various problems in traditional construction management mode. Taking Kunchu Expressway over Chengdu-Kunming Railway Bridge as an example, this paper introduces the technical route and technical application points of fine management of construction of turning bridge of Expressway based on BIM technology. The main application points of this paper include: BIM collaboration, BIM collision detection, BIM project management application platform, UAV three-dimensional scene modeling, three-dimensional laser scanning. Practice has proved that BIM technology has incomparable advantages over traditional management mode in finding drawings errors, technical submission, engineering statistics, collision detection, information integration and so on. The implementation of BIM technology has brought enormous technical and economic benefits to project management and has good prospects for promotion.

Swivel bridge has the characteristics of complex construction environment, difficult construction, high requirement, tight construction period, many coordination relations and huge amount of information. Based on the BIM technology, the project information management platform carries out fine management of the project, focusing on the functional planning and overall framework of the platform. On this basis, the letter is elaborated in detail. Information management, progress management, construction simulation, progress difference analysis, task collaboration, quality improvement collaboration, safety issues collaboration and other important functional modules. Practice has proved that, compared with the traditional model, the project information management platform based on BIM technology has obvious advantages in saving costs, improving the degree of management refinement, and training BIM reserve personnel, and has a good prospect for promotion.

EPC projects with large engineering and procurement volumes, long construction cycles and management difficulties, the risks faced are also more complex and varied than in other contracting models. This paper establishes a risk index system by documentary method and evaluates and calculates the cost risk in two different environments at home and abroad by hierarchical analysis, so as to find the similarities and differences and propose countermeasures to provide a basis for risk management in China’s EPC contracting model.

Long intergenic noncoding ribonucleic acid (lncRNA) 460 is reportedly associated with carcinogenesis and progression in various types of cancer. However, the mechanisms underlying its action in cutaneous squamous cell carcinoma (CSCC) remain unclear. LINC00460 mRNA expression was analysed using data from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Cell growth, migration, and invasion were evaluated using Cell Counting Kit-8 (CCK-8), 5-ethynyl-2′-deoxyuridine (EdU), transwell migration and invasion assays after inducing LINC00460 knockdown. A xenograft tumour model was used to determine the effects of LINC00460 on tumour growth and metastasis in vivo. To examine the interaction between LINC00460 and ELAVL1, RNA pulldown and RNA immunoprecipitation assays were performed. LINC00460 was found to be significantly upregulated in CSCC tissues and cell lines. Functionally, LINC00460 knockdown inhibited cell proliferation, migration, and invasion in vitro. Consistent with this, when LINC00460 expression decreased, CSCC tumorigenesis and metastasis in vivo were inhibited. Mechanistically, LINC00460 binds to embryonic lethal abnormal vision like RNA binding protein 1 (ELAVL1) and enhances its stability by inhibiting the β-transducin repeats-containing protein (β-TrCP)-mediated ubiquitination of ELAVL1. Moreover, the effect of LINC00460 silencing on the proliferation, migration, and invasion of CSCC cells could be reversed by overexpressing ELAVL1. Our findings demonstrated that LINC00460 plays a critical role in regulating ELAVL1 function. This highlights the potential targets for the clinical diagnosis and treatment of CSCC.