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The goal is to reveal the relationship between the score SYNTAX score and the development of postoperative atrial fibrillation (AF). Materials and methods. Retrospective study included 156 patients (mean age 59±7 years) undergoing an isolated coronary bypass (CB). Exclusion criteria were: AF in the anamnesis, lesions of the valvular heart apparatus, diameter of the left atrium more than 50 mm, repeated surgical interventions on the heart. SYNTAX score, clinical, laboratory and echocardiographic parameters were evaluated. Results. The average score of the SYNTAX score was 26.7; postoperative AF was detected in 23 (14.7%) patients. Statistically significant differences were revealed during the time of mechanical ventilation (10.6±5.9 in comparison with 21.6±33.5, p=0.001) and SYNTAX score (25.7±8.7 vs 32.7±11.4, p=0.001). SYNTAX score and time of artificial ventilation are independent predictors of postoperative AF. Conclusion: a high score SYNTAX score is associated with a more frequent postoperative rhythm disturbance in the type of AF in patients undergoing an isolated CB.